Antibiotics are drugs used to treat bacterial infections, but they can cause more harm than good when not used properly. Reports have shown that non-prescription sale of antibiotics is prevalent in all communities of the world. However, the role of community pharmacy in ensuring the safe use of antibiotics in this region has not been evaluated as bacterial resistant pattern are changing, according to reports. This study was carried out in order to identify the non-prescription use/ dispensing of antibiotics and pharmacists attitude in ensuring safe use of antibiotics in the community. A qualitative study design was adopted to interview fifteen pharmacists practicing on the community pharmacies in eastern region, Al-Ahsa, Kingdom of Saudi Arabia. Data obtained was coded independently for the relevant themes. Findings demonstrate that consumers often request for the antibiotics without prescription, especially the antibiotics i.e amoxicillin and ciprofloxacin. Most of them purchase based on their personal experience either for prophylaxis or to get relief from the symptoms. Diarrhea and itching are the only adverse event that the pharmacists have noticed among the consumers. The current study reveals significant incidence of misuse and malpractice regarding antibiotic sale by community pharmacies in Al-Ahsa.