Epstein-Barr virus is a member of Herpesviridae family and it is the cause of infectious mononucleosis (IM) disease. While 50% of the patients having IM have high serum aminotransferases, clinically, a real hepatitis is seen rarely. Presentation of IM with hepatitis clinic without its other symptoms is not a common condition. Jaundice is especially uncommon so it isn’t the presentation symptom generally. When making the differential diagnosis of acute hepatitis, peripheral blood smear examination was crucial, in order toreveal atypical lymphocytes suggesting IM. In this report we presented a patient with icteric IM hepatitis who have atypical lymphocytes on his peripheral blood smear.