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REVIEW ARTICLE
A comprehensive review on the pancreatic lipase inhibitory peptides: A future anti-obesity strategy
1
Analytical Biochemistry Research Centre (ABrC), Universiti Innovation Incubator Building, SAINS@USM Campus, Universiti Sains Malaysia, Lebuh Bukit Jambul 11900, Penang, MALAYSIA
2
College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin, SAUDI ARABIA
3
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MALAYSIA
4
Center for Drug Research, Universiti Sains Malaysia, Penang, MALAYSIA
5
Department of Physiology, School of Medicine, University College of Cork, Cork, IRELAND
Online publication date: 2023-03-07
Publication date: 2023-05-01
Electron J Gen Med 2023;20(3):em470
KEYWORDS
anti-obesitydrug developmentinhibitory peptidesmolecular dockingpancreatic lipasestructural activity relationship
ABSTRACT
Dysregulation of lipid homeostasis contributes to obesity and can directly lead to several critical public health concerns globally. This paper aimed to present a brief review of related properties and the use of pancreatic lipase inhibitors as the future weight loss drug discovery and development procured from a wide range of natural sources. A total of 176 pancreatic lipase inhibitory peptides were identified from recent publications and peptide databases. These peptides were classified into three categories according to their peptide length and further analyzed using bioinformatic approaches to identify their structural activity relationship. Molecular docking analyses were conducted for each amino acid at the terminal position of the peptides to predict the binding affinity between peptide-enzyme protein complexes based on intermolecular contact interactions. Overall, the observations revealed the features of the inhibitory peptides and their inhibitory mechanisms and interactions. These findings strived to benefit scientists whose research may be relevant to anti-obesity drug development and/or discovery thereby support effective translation of preclinical research for humans’ health being.
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