Angiomyofibroblastoma is a rare,benign,well-circumscribed neoplasm predominantly occurring in the pelviperineal region of middle-aged women. The tumour cells are round-to-spindle shaped concentrated around vessels. They almost have immunoreactivity for desmin and vimentin,consistently positive for estrogen and progesterone receptors,occasionally positive for CD 34. The complete surgical excision of the tumour is necessary. It is important to distinguish this tumour from especially aggressive angiomyxoma to avoid inadequate treatment. Here,we report a case of vulvar angiomyofibroblastoma in a 46-year old postmenopausal woman whose findings were differentiating from others. Histologically,the tumour involved fibroadipose tissue and immunoreactivity for desmin and actin was negative.