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ORIGINAL ARTICLE
Arabic gum as a natural therapeutic agent for diabetic patients with CKD: A retrospective study
1
Division of Nephrology, Department of Internal Medicine, The University of Jordan, Amman, JORDAN
2
Division of Nephrology, Department of Internal Medicine, Jordan University of Science and Technology, Irbid, JORDAN
3
Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, UAE
4
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, JORDAN
Online publication date: 2023-04-12
Publication date: 2023-07-01
Electron J Gen Med 2023;20(4):em497
KEYWORDS
ABSTRACT
Arabic gum (AG) is a dietary additive widely used in food manufacture and drugs; it has also gained popularity as herbal tea that can cure diseases such as diabetes, hypertension, and chronic kidney disease. Studies showed its antioxidant and anti-inflammatory effects. In a retrospective study design, we included CKD patients taking AG for at least three months. Data were collected over one year for each patient: age, co-morbidities, duration, amount of AG used, serum creatinine, inflammatory markers, lipid profile, blood sugar, hemoglobin A1C, and blood pressure readings. For the changes in values and trends, we compared the values individually for each patient separately. A total of 30 patients consisted of 20 males (66.7%) and 10 females (33.3%), with a mean age of 63.2 years. The mean (M) eGFR pre-enrollment in the study was 23.5 ml/min (standard deviation [SD]=15.8), and the mean eGFR at the end of the study was 26.1 ml/min (SD=18.9, p=0.56). There was a significant difference in the eGFR after using AG between diabetics (M=31.3 ml/min, SD=18.5) and non-diabetics (M=20.5 ml/min, SD=18.2, p=0.03). With a history of catheterization, there was a significant difference in eGFR between patients who had catheterization (M=31.76, SD=20.86) and patients without catheterization (M=18.36, SD=13.08, p=0.04). No significant effect on lipid profile, or CRP, yet significant effect on blood sugar control (fasting blood sugar 0.0001, and HBAa1c 0.01). In conclusion, AG is a promising natural material that affects decreasing eGFR in CKD diabetics patients.
REFERENCES (53)
1.
Padil VVT, Wacławek S, Černík M, Varma RS. Tree gum-based renewable materials: Sustainable applications in nanotechnology, biomedical and environmental fields. Biotechnol Adv. 2018;36(7):1984-2016. https://doi.org/10.1016/j.biot... PMid:30165173 PMCid:PMC6209323.
2.
Gonçalves JP, da Cruz AF, Nunes ÁM, et al. Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas. Int J Biol Macromol. 2021;185:551-61. https://doi.org/10.1016/j.ijbi... PMid:34216657.
3.
Liang Q, Ma P, Zhang Q, et al. A gum arabic assisted sustainable drug delivery system for adult drosophila. Biol Open 2020;9(6):bio052241. https://doi.org/10.1242/bio.05... PMid:32487516 PMCid:PMC7328006.
4.
Raguvaran R, Manuja A, Manuja BK, et al. Sodium alginate and gum acacia hydrogels of zinc oxide nanoparticles reduce hemolytic and oxidative stress inflicted by zinc oxide nanoparticles on mammalian cells. Int J Biol Macromol. 2017;101:967-72. https://doi.org/10.1016/j.ijbi... PMid:28373047.
5.
Giorgetti A, Husmann FMD, Zeder C, Herter-Aeberli I, Zimmermann MB. Prebiotic galacto-oligosaccharides and fructo-oligosaccharides, but not acacia gum, increase iron absorption from a single high-dose ferrous fumarate supplement in iron-depleted women. J Nutr. 2022;152(4):1015-21. https://doi.org/10.1093/jn/nxa....
6.
Al-Jubori Y, Ahmed NTB, Albusaidi R, Madden J, Das S, Sirasanagandla SR. The efficacy of gum arabic in managing diseases: A systematic review of evidence-based clinical trials. Biomolecules. 2023;13(1):138. https://doi.org/10.3390/biom13... PMid:36671523 PMCid:PMC9855968.
7.
Ali BH, Al-Husseni I, Beegam S, et al. Effect of gum arabic on oxidative stress and inflammation in adenine-induced chronic renal failure in rats. PloS One 2013;8(2):e55242. https://doi.org/10.1371/journa... PMid:23383316 PMCid:PMC3562323.
8.
Ali BH, Al-Salam S, Al Husseni I, et al. Effects of gum arabic in rats with adenine-induced chronic renal failure. Exp Biol Med (Maywood). 2010;235(3):373-82. https://doi.org/10.1258/ebm.20... PMid:20404056.
9.
El-Garawani I, Hassab El-Nabi S, El Kattan A, et al. The ameliorative role of acacia senegal gum against the oxidative stress and genotoxicity induced by the radiographic contrast medium (ioxitalamate) in albino rats. Antioxidants (Basel). 2021;10(2):221. https://doi.org/10.3390/antiox... PMid:33540787 PMCid:PMC7912984.
10.
Al Za’abi M, Al Salam S, Al Suleimani Y, Manoj P, Nemmar A, Ali BH. Gum acacia improves renal function and ameliorates systemic inflammation, oxidative and nitrosative stress in streptozotocin-induced diabetes in rats with adenine-induced chronic kidney disease. Cell Physiol Biochem. 2018;45(6):2293-304. https://doi.org/10.1159/000488... PMid:29550811.
11.
Ali BH, Ziada A, Al Husseni I, Beegam S, Nemmar A. Motor and behavioral changes in rats with adenine-induced chronic renal failure: Influence of acacia gum treatment. Exp Biol Med (Maywood). 2011;236(1):107-12. https://doi.org/10.1258/ebm.20... PMid:21239740.
12.
Mohammed ME, Abbas AM, Badi RM, et al. Effect of acacia senegal on tgf-β1 and vascular mediators in a rat model of diabetic nephropathy. Arch Physiol Biochem. 2022;128(6):1548-58. https://doi.org/10.1080/138134... PMid:32574082.
13.
Roozbeh N, Darvish L, Abdi F. Hypoglycemic effects of acacia nilotica in type ii diabetes: A research proposal. BMC Res Notes. 2017;10(1):331. https://doi.org/10.1186/s13104... PMid:28747209 PMCid:PMC5530526.
14.
Ali AA, Ali KE, Fadlalla AE, Khalid KE. The effects of gum arabic oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in central sudan. Nat Prod Res. 2008;22(1):12-21. https://doi.org/10.1080/147864... PMid:17999333.
15.
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-12. https://doi.org/10.7326/0003-4... PMid:19414839 PMCid:PMC2763564.
16.
Alshelleh SA, Oweis AO, Alzoubi KH. Acute kidney injury among nonagenarians in Jordan: A retrospective case-control study. Int J Nephrol Renovasc Disease. 2018;11:337-42. https://doi.org/10.2147/IJNRD.... PMid:30555251 PMCid:PMC6280911.
17.
Ali BH, Ziada A, Blunden G. Biological effects of gum arabic: A review of some recent research. Food Chem Toxicol. 2009;47(1):1-8. https://doi.org/10.1016/j.fct.... PMid:18672018.
18.
Shafeek F, Abu-Elsaad N, El-Karef A, Ibrahim T. Gum acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways. Food Chem Toxicol. 2019;129:162-8. https://doi.org/10.1016/j.fct.... PMid:31042592.
19.
Ali BH, Al Za’abi M, Al Suleimani Y, et al. Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(8):1427-36. https://doi.org/10.1007/s00210... PMid:32157347.
20.
Al Suleimani YM, Al Za’abi M, Ramkumar A, et al. Influence of treatment with gum acacia on renal vascular responses in a rat model of chronic kidney disease. Eur Rev Med Pharmacol Sci. 2015;19(3):498-506.
21.
Alarifi S, Bell A, Walton G. In vitro fermentation of gum acacia–Impact on the faecal microbiota. Int J Food Sci Nutr. 2018;69(6):696-704. https://doi.org/10.1080/096374... PMid:29334803.
22.
Tsai YL, Lin TL, Chang CJ, et al. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019;26(1):3. https://doi.org/10.1186/s12929... PMid:30609922 PMCid:PMC6320572.
23.
Lopes RDCS, Balbino KP, Jorge MP, Ribeiro AQ, Martino HSD, Alfenas RCG. Modulation of intestinal microbiota, control of nitrogen products and inflammation by pre/probiotics in chronic kidney disease: A systematic review. Nutr Hosp. 2018;35(3):722-30. https://doi.org/10.20960/nh.16....
24.
Koppe L, Fouque D, Soulage CO. Metabolic abnormalities in diabetes and kidney disease: Role of uremic toxins. Curr Diab Rep. 2018;18(10):97. https://doi.org/10.1007/s11892... PMid:30194541.
25.
Lakshmanan AP, Al Za’abi M, Ali BH, Terranegra A. The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease. Biomed Pharmacother. 2021;133:110992. https://doi.org/10.1016/j.biop... PMid:33202283.
26.
Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease–A systematic review and meta-analysis. PloS One. 2016;11(7):e0158765. https://doi.org/10.1371/journa... PMid:27383068 PMCid:PMC4934905.
27.
Ueda N, Takasawa K. Impact of inflammation on ferritin, hepcidin and the management of iron deficiency anemia in chronic kidney disease. Nutrients. 2018;10(9):1173. https://doi.org/10.3390/nu1009... PMid:30150549 PMCid:PMC6163440.
28.
Mihai S, Codrici E, Popescu ID, et al. Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome. J Immunol Res. 2018;2018:2180373. https://doi.org/10.1155/2018/2... PMid:30271792 PMCid:PMC6146775.
29.
Elamin S, Alkhawaja MJ, Bukhamsin AY, et al. Gum arabic reduces c-reactive protein in chronic kidney disease patients without affecting urea or indoxyl sulfate levels. Int J Nephrol. 2017;2017:9501470. https://doi.org/10.1155/2017/9... PMid:28589039 PMCid:PMC5446885.
30.
Amdur RL, Feldman HI, Gupta J, et al. Inflammation and progression of ckd: The cric study. Clin J Am Soc Nephrol. 2016;11(9):1546-56. https://doi.org/10.2215/CJN.13... PMid:27340285 PMCid:PMC5012490.
31.
Akchurin OM, Kaskel F. Update on inflammation in chronic kidney disease. Blood Purif. 2015;39(1-3):84-92. https://doi.org/10.1159/000368... PMid:25662331.
32.
Bilen Y, Cankaya E, Keles M, et al. Does decreased mean platelet volume predict inflammation in chronic renal failure, dialysis, and transplanted patients? Ren Fail. 2014;36(1):69-72. https://doi.org/10.3109/088602... PMid:24028675.
33.
Rapa SF, Di Iorio BR, Campiglia P, Heidland A, Marzocco S. Inflammation and oxidative stress in chronic kidney disease-potential therapeutic role of minerals, vitamins and plant-derived metabolites. Int J Mol Sci. 2019;21(1):263. https://doi.org/10.3390/ijms21... PMid:31906008 PMCid:PMC6981831.
34.
Asgharpour M, Alirezaei A. Herbal antioxidants in dialysis patients: A review of potential mechanisms and medical implications. Ren Fail. 2021;43(1):351-61. https://doi.org/10.1080/088602... PMid:33593237 PMCid:PMC7894453.
35.
Gautam G, Parveen B, Umar Khan M, et al. A systematic review on nephron protective AYUSH drugs as constituents of NEERI-KFT (a traditional indian polyherbal formulation) for the management of chronic kidney disease. Saudi J Biol Sci. 2021;28(11):6441-53. https://doi.org/10.1016/j.sjbs... PMid:34764761 PMCid:PMC8568826.
36.
Vallianou NG, Mitesh S, Gkogkou A, Geladari E. Chronic kidney disease and cardiovascular disease: Is there any relationship? Curr Cardiol Rev. 2019;15(1):55-63. https://doi.org/10.2174/157340... PMid:29992892 PMCid:PMC6367692.
37.
Lessey G, Stavropoulos K, Papademetriou V. Mild to moderate chronic kidney disease and cardiovascular events in patients with type 2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:365-73. https://doi.org/10.2147/VHRM.S... PMid:31686830 PMCid:PMC6709811.
38.
Chen S-C, Huang J-C, Su H-M, et al. Prognostic cardiovascular markers in chronic kidney disease. Kidney Blood Press Res. 2018;43(4):1388-407. https://doi.org/10.1159/000492... PMid:30153666.
39.
Jarrar AH, Stojanovska L, Apostolopoulos V, et al. The effect of gum arabic (acacia senegal) on cardiovascular risk factors and gastrointestinal symptoms in adults at risk of metabolic syndrome: A randomized clinical trial. Nutrients. 2021;13(1):194. https://doi.org/10.3390/nu1301... PMid:33435475 PMCid:PMC7826716.
40.
Wan EYF, Yu EYT, Chin WY, et al. Burden of CKD and cardiovascular disease on life expectancy and health service utilization: A cohort study of hong kong chinese hypertensive patients. J Am Soc Nephrol. 2019;30(10):1991-9. https://doi.org/10.1681/ASN.20... PMid:31492808 PMCid:PMC6779363.
41.
Koye DN, Magliano DJ, Reid CM, et al. Risk of progression of nonalbuminuric CKD to end-stage kidney disease in people with diabetes: The CRIC (chronic renal insufficiency cohort) study. Am J Kidney Dis. 2018;72(5):653-61. https://doi.org/10.1053/j.ajkd... PMid:29784612.
42.
Thomas MC, Cooper ME, Zimmet P. Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nat Rev Nephrol. 2016;12(2):73-81. https://doi.org/10.1038/nrneph... PMid:26553517.
43.
Levey AS, Bilous R, Shlipak MG. CKD and diabetes: What can we learn from their similarities and differences? Am J Kidney Dis. 2016;67(3):360-3. https://doi.org/10.1053/j.ajkd... PMid:26916373.
44.
Thomas MC, Brownlee M, Susztak K, et al. Diabetic kidney disease. Nat Rev Dis Primers. 2015;1:15018. https://doi.org/10.1038/nrdp.2... PMid:27188921 PMCid:PMC7724636.
45.
Anders HJ, Huber TB, Isermann B, Schiffer M. CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease. Nat Rev Nephrol. 2018;14(6):361-77. https://doi.org/10.1038/s41581... PMid:29654297.
46.
Juhász AE, Greff D, Teutsch B, et al. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: A systematic review and network meta-analysis. Am J Clin Nutr. 2023;117(2):266-77. https://doi.org/10.1016/j.ajcn... PMid:36811560.
47.
Babiker R, Elmusharaf K, Keogh MB, Saeed AM. Effect of gum arabic (acacia senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): A randomized and placebo-controlled clinical trial. Lipids Health Dis. 2018;17(1):56. https://doi.org/10.1186/s12944... PMid:29558953 PMCid:PMC5859434.
48.
Namazi N, Larijani B, Azadbakht L. Are isolated and complex fiber supplements good choices for weight management? A systematic review. Arch Iran Med. 2017;20(11):704-13.
49.
Ding YY, Pan Y, Zhang W, et al. Preparation of gum arabic-maltose-pea protein isolate complexes for 1-octacosanol microcapsule: Improved storage stability, sustained release in the gastrointestinal tract, and its effect on the lipid metabolism of high-fat-diet-induced obesity mice. Foods. 2022;12(1):112. https://doi.org/10.3390/foods1... PMid:36613328 PMCid:PMC9818909.
50.
Jangra S, Pothuraju R. Functional significance of gum acacia in the management of obesity. Curr Pharm Des. 2020;26(3):293-5. https://doi.org/10.2174/138161... PMid:32213150.
51.
Liu M, Li XC, Lu L, et al. Cardiovascular disease and its relationship with chronic kidney disease. Eur Rev Med Pharmacol Sci. 2014;18(19):2918-26.
52.
Fujii H, Joki N. Mineral metabolism and cardiovascular disease in CKD. Clin Exp Nephrol. 2017;21(Suppl 1):53-63. https://doi.org/10.1007/s10157... PMid:28062938.
53.
Gregg LP, Hedayati SS. Management of traditional cardiovascular risk factors in CKD: What are the data? Am J Kidney Dis. 2018;72(5):728-44. https://doi.org/10.1053/j.ajkd... PMid:29478869 PMCid:PMC6107444.
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