Current issue
Archive
About the Journal
About us
Aims and Scope
Indexing and Abstracting
Editorial Office
Open Access Policy
Publication Ethics
Contact
For Authors
Editorial Policy
Peer Review Policy
Manuscript Preparation Guidelines
Copyright & Licensing
Publication Fees
Fast-Track Paper Publication Option
Conflict Interest Guidance
Submit an Article
Special Issues
News & Editorials
“Fake,” “Predatory,” and “Pseudo” Journals: Charlatans Threatening Trust in Science
Shifting the Journal submission-review system to the Editorial System Manuscript December 27, 2017.
REVIEW ARTICLE
COVID-19 Treatment: The Race Against Time
1
Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, KAZAKHSTAN
2
Department of Clinical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, KAZAKHSTAN
Online publication date: 2020-04-05
Publication date: 2020-04-05
Electron J Gen Med 2020;17(6):em227
KEYWORDS
COVID-19treatmentclinical trialsChloroquineLopinavir-ritonavirRemdesivirTocilizumabCamostat mesilate
ABSTRACT
The new outbreak of the novel coronavirus infection emerged in Wuhan- China in late 2019, by the end of Mar 2020, it has spread in more than 178 countries and territories. There is no vaccine or antiviral treatment for COVID-19. Currently, there are several drugs and vaccines being tested for their potential activity against the disease. In this review, we briefly discuss some of the investigational drugs and vaccines being tested against COVID-19 as well as their potential drawbacks.
REFERENCES (19)
1.
Aljofan M, Gaipov A. Chloroquine and COVID-19: A Light at the End of the Tunnel, or is it Another Train?. Electron J Gen Med. 2020;17(4):em207. https://doi.org/10.29333/ejgm/....
2.
Zhao H, Wald J, Palmer M, Han Y. Hydroxychloroquine-induced cardiomyopathy and heart failure in twins. Journal of thoracic disease. 2018;10(1):E70. https://doi.org/10.21037/JTD.2... PMID:29600108 PMCID:PMC5863196.
3.
Zeldin RK, Petruschke RA. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. Journal of antimicrobial chemotherapy. 2004;53(1):4-9. https://doi.org/10.1093/jac/dk... PMID:14657084.
4.
Chu C, Cheng V, Hung I, Wong M, Chan K, Chan K, et al. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax. 2004;59(3):252-6. https://doi.org/10.1136/thorax... PMID:14985565 PMCID:PMC1746980.
5.
Park S, Lee J, Son J, Ko J, Peck K, Jung Y, et al. Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers. Journal of Hospital Infection. 2019;101(1):42-6. https://doi.org/10.1016/j.jhin... PMID:30240813 PMCID:PMC7114948.
6.
De Clercq E. New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. Chemistry–An Asian Journal. 2019;14(22):3962-8. https://doi.org/10.1002/asia.2... PMID:31389664.
7.
Tchesnokov EP, Feng JY, Porter DP, Götte M. Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir. Viruses. 2019;11(4):326. https://doi.org/10.3390/v11040... PMID:30987343 PMCID:PMC6520719.
8.
Yethindra V. Role of GS-5734 (Remdesivir) in inhibiting SARS-CoV and MERS-CoV: The expected role of GS-5734 (Remdesivir) in COVID-19 (2019-nCoV)-VYTR hypothesis. International Journal of Research in Pharmaceutical Sciences. 2020;11(SPL1):1-6. https://doi.org/10.26452/ijrps....
9.
NIH clinical trial of remdesivir to treat COVID-19 begins. U.S. https://www.nih.gov/news-event... [press release]. U.S. Department of Health and Human ServicesFebruary 25, 2020.
10.
Clinical trials on Remdesivir and COVID-19 [cited 2020 April 2]. Available at: https://clinicaltrials.gov/ct2....
11.
Mulangu S, Dodd LE, Davey Jr RT, Tshiani Mbaya O, Proschan M, Mukadi D, et al. A randomized, controlled trial of Ebola virus disease therapeutics. New England Journal of Medicine. 2019;381(24):2293-303. https://doi.org/10.1056/NEJMoa... PMID:31774950.
12.
Sebba A. Tocilizumab: the first interleukin-6-receptor inhibitor. American Journal of Health-System Pharmacy. 2008;65(15):1413-8. https://doi.org/10.2146/ajhp07... PMID:18653811.
13.
Maini R, Taylor P, Szechinski J, Pavelka K, Bröll J, Balint G, et al. Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis & Rheumatism. 2006;54(9):2817-29. https://doi.org/10.1002/art.22... PMID:16947782.
14.
Shimabukuro-Vornhagen A, Gödel P, Subklewe M, Stemmler HJ, Schlößer HA, Schlaak M, et al. Cytokine release syndrome. Journal for immunotherapy of cancer. 2018;6(1):56. https://doi.org/10.1186/s40425... PMID:29907163 PMCID:PMC6003181.
15.
Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. The Lancet. 2020;395(10223):473-5. https://doi.org/10.1016/S0140-....
16.
Chinese Clinical Trial Registry. A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19). 2020 [Available at: http://www.chictr.org.cn/showp....
17.
Yamauchi J-i, Takeda K, Shibuya K, Sunamura M, Matsuno S. Continuous Regional Application of Protease Inhibitor in the Treatment of Acute Pancreatitis. Pancreatology. 2001;1(6):662-7. https://doi.org/10.1159/000055... PMID:12120251.
18.
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426(6965):450-4. https://doi.org/10.1038/nature... PMID:14647384 PMCID:PMC7095016.
19.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020. https://doi.org/10.1016/j.cell... PMID:32142651 PMCID:PMC7102627.
Share
RELATED ARTICLE
| eISSN: | 2516-3507 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
