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ORIGINAL ARTICLE
Clinical and morphological changes of the spleen in COVID-19 patients with and without splenectomy
1
Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA
2
Institute of Linguistics and Intercultural Communication, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA
3
Department of Basic Sciences, College of Medicine, Ajman University, Ajman, UAE
4
Department of Biology and General Genetics, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA
5
Department of Polyclinic Therapy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA
Online publication date: 2024-08-10
Publication date: 2024-09-01
Electron J Gen Med 2024;21(5):em602
KEYWORDS
splenic abscesssplenic infractionCOVID-19ultrasoundsplenectomyincidencedisease patternsecondary immunodeficiency
ABSTRACT
Patients diagnosed with COVID-19 were seen to develop splenic infarction or abscess. This study aims to estimate
the incidence of splenic infarction/abscess in COVID-19 patients and to examine the clinical and morphological
changes in the infected spleen. In the splenectomy group, 63.5% of patients had an enlarged spleen measuring
between 12.1 cm × 5.1 cm and 19.2 cm × 12.2 cm. The incidence of splenic infarction was 36.4%, while the incidence
of splenic infarction complicated by abscess was 18.1%. The size of splenic infarcts varied from 3.1 cm × 1.4 cm to
10.2 cm × 4.3 cm. Splenic abscesses were present in 72.3% of patients. Of 596 patients with severe COVID-19, 12
had at least one splenic abscess (2.3%): three patients had multiple splenic abscesses, while the rest had a single
abscess pocket. Splenic infarction was found in 116 patients (22.5%), including 6 patients who later developed
splenic abscesses.
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