Confluent cavitated nodules in invasive mucinous adenocarcinoma: A case report

Invasive mucinous adenocarcinoma is a rare variant of lung adenocarcinoma. Here, we present the case of a patient with invasive mucinous adenocarcinoma with cavitary lung lesions. A 61-year-old painter-and-bricklayer. She was admitted due to mMRC2 dyspnea, a dry cough that during hospitalization mobilizes dense, abundant secretions, and becomes demanding. Differential diagnoses were made based on clinical symptoms and images, performing multiple laboratory tests ruling out immunosuppression, and two video-bronchofibroscopies finding the diagnosis in the transbronchial lung biopsy: Invasive mucinous adenocarcinoma that would explain the abundant bronchorrhea, advanced stage and poor prognosis led to ventilatory failure and death of the patient.

REFERENCES (13)

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. https://doi.org/10.3322/caac.2... PMid:33538338.

CrossRef

Pubmed

Google Scholar

Fan L, Fang MJ, Li ZB, et al. Radiomics signature: A biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule. Eur Radiol. 2019;29(2):889-97. https://doi.org/10.1007/s00330... PMid:29967956.

CrossRef

Pubmed

Google Scholar

Geles A, Gruber-Moesenbacher U, Quehenberger F, et al. Pulmonary mucinous adenocarcinomas: Architectural patterns in correlation with genetic changes, prognosis and survival. Virchows Arch. 2015;467(6):675-86. https://doi.org/10.1007/s00428... PMid:26450556.

CrossRef

Pubmed

Google Scholar

Lee HY, Cha MJ, Lee KS, et al. Prognosis in resected invasive mucinous adenocarcinomas of the lung: Related factors and comparison with resected nonmucinous adenocarcinomas. J Thorac Oncol. 2016;11(7):1064-73. https://doi.org/10.1016/j.jtho... PMid:27016260.

CrossRef

Pubmed

Google Scholar

Shim HS, Mari-Kenudson, Zheng Z, et al. Unique genetic and survival characteristics of invasive mucinous adenocarcinoma of the lung. J Thorac Oncol. 2015;10(8):1156-62. https://doi.org/10.1097/JTO.00... PMid:26200269.

CrossRef

Pubmed

Google Scholar

Verma R, Bhalla AS, Goyal A, Jain D, Loganathan N, Guleria R. Ominous lung cavity “tambourine sign”. World J Clin Cases. 2017;5(4):1538. https://doi.org/10.12998/wjcc.... PMid:28470008 PMCid:PMC5395984.

Nakamura S, Sugimoto H, Negoro K, Tanaka R. Invasive mucinous adenocarcinoma of the lung presenting with multiple cavities. Cureus. 2021;13(3):e13795. https://doi.org/10.7759/cureus....

CrossRef

Google Scholar

Masuzawa K, Minematsu N, Sasaki M, et al. Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review. Mol Clin Oncol. 2017;6(3):433-7. https://doi.org/10.3892/mco.20... PMid:28451428 PMCid:PMC5403370.

Gagnier JJ, Kienle G, Altman DG, et al. The CARE guidelines: Consensus-based clinical case reporting guideline development. J Clin Epidemiol. 2014;67(1):46-51. https://doi.org/10.1016/j.jcli... PMid:24035173.

CrossRef

Pubmed

Google Scholar

10.

Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6(2):244-85. https://doi.org/10.1097/JTO.0b... PMid:21252716 PMCid:PMC4513953.

11.

Barrionuevo, C. Tipos moleculares de carcinoma pulmonar en el Instituto Nacional de Enfermedades Neoplásicas en pacientes atendidos entre los años 2007 y 2013 [Molecular types of lung carcinoma at the National Institute of Neoplastic Diseases in patients seen between 2007 and 2013] [Doctoral thesis]. Lima: Universidad Nacional Mayor de San Marcos; 2020.

Google Scholar

12.

Wang T, Yang Y, Liu X, et al. Primary invasive mucinous adenocarcinoma of the lung: Prognostic value of CT imaging features combined with clinical factors. Korean J Radiol. 2020;22(4):652-62. https://doi.org/10.3348/kjr.20... PMid:33236544 PMCid:PMC8005341.

13.

Morichika D, Miyahara N, Hotta K, et al. Invasive mucinous adenocarcinoma mimicking organizing pneumonia associated with mycobacterium fortuitum infection. Intern Med. 2014;53(24):2795-9. https://doi.org/10.2169/intern... PMid:25500441.