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REVIEW ARTICLE
Defining a Physiological Role for the Tubulin Tyrosination Cycle
1
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Online publication date: 2004-04-15
Publication date: 2004-04-15
Corresponding author
Haitham T. Idriss
233 S. 10th St., BLSB 904 Philadelphia, PA 19107-5541. USA. Tel: 215-503 4631 Fax: 215-923 1098
233 S. 10th St., BLSB 904 Philadelphia, PA 19107-5541. USA. Tel: 215-503 4631 Fax: 215-923 1098
Eur J Gen Med 2004;1(2):1-2
KEYWORDS
ABSTRACT
This paper proposes, based on data from other laboratories, that the physiological function of the tubulin tyrosination cycle is to maintain a check for normal physiological milieu within cells,
whereby tyrosine and nitrotyrosine act as markers for normality and abnormality, respectively.
Incorporation of nitrotyrosine is postulated to initiate apoptosis to facilitate elimination of
abnormal cells.
| eISSN: | 2516-3507 |
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