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ORIGINAL ARTICLE
Effect of Juglansregia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats
1
Department of Biology, College of sciences, Fars Science and Research Branch, Islamic Azad University, Fras, Iran
2
Department of Biology, College of sciences, Shiraz Branch. Islamic Azad university, Shiraz, Iran
3
Department of physiology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4
Department of Anatomy, Medicinal Plants Research Center, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
5
Department of Biology, Islamic Azad University, Kazerun Branch, Kazerun, Iran
Publication date: 2018-03-03
Corresponding author
Jamshid Mohammadi
Department of physiology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Department of physiology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Electron J Gen Med 2018;15(3):em30
KEYWORDS
ABSTRACT
Background:
Juglans regia contain compounds such as phenolic acids and flavonoids. Experimental studies demonstrated the Juglans regia were used in traditional medicine and has many beneficial effects. Use of Nasturtum officinalis has been reported to prevent cellular damage and elevate the level of antioxidant in the body. Nasturtum officinalis extract had Strong antioxidant properties and beneficial effects on reducing blood lipids. The purpose of this research is to determine the effect of Juglans regia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats.
Materials and Methods:
Sixty four Wistar rats were used and divided into 8 groups of eight animals each. Wistar rats were received intraperitoneally 50% CCl4 in olive oil. Juglans regia leaves and Nasturtum officinalis were orally administered before or after CCl4 in treatment groups twice a week for 31 days. After twenty one day, the blood samples were collected of all rats and serum levels of biochemical parameters were measured.
Results:
In treatment groups, serum BUN, Bun, Alb, creatinine, Blood Urea, Uric acid levels were significantly decreased in comparison to their positive group. Also at the end of experiment, serum ALP, AST and ALT activity decreased significantly in treatment groups when compared with Positive group.
Conclusion:
This study suggests that CCl4 induced liver and kidney damage in rats can be ameliorated by administration of extract of J. regia and N. officinalis.
Juglans regia contain compounds such as phenolic acids and flavonoids. Experimental studies demonstrated the Juglans regia were used in traditional medicine and has many beneficial effects. Use of Nasturtum officinalis has been reported to prevent cellular damage and elevate the level of antioxidant in the body. Nasturtum officinalis extract had Strong antioxidant properties and beneficial effects on reducing blood lipids. The purpose of this research is to determine the effect of Juglans regia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats.
Materials and Methods:
Sixty four Wistar rats were used and divided into 8 groups of eight animals each. Wistar rats were received intraperitoneally 50% CCl4 in olive oil. Juglans regia leaves and Nasturtum officinalis were orally administered before or after CCl4 in treatment groups twice a week for 31 days. After twenty one day, the blood samples were collected of all rats and serum levels of biochemical parameters were measured.
Results:
In treatment groups, serum BUN, Bun, Alb, creatinine, Blood Urea, Uric acid levels were significantly decreased in comparison to their positive group. Also at the end of experiment, serum ALP, AST and ALT activity decreased significantly in treatment groups when compared with Positive group.
Conclusion:
This study suggests that CCl4 induced liver and kidney damage in rats can be ameliorated by administration of extract of J. regia and N. officinalis.
REFERENCES (26)
1.
Vahidirad M, Arab-Nozari M, Mohammadi H, Zamani E, Shaki F. Protective effect of captopril against diazinon induced nephrotoxicity and neurotoxicity via inhibition of ROS-NO pathway. Drug ChemToxicol 2017;8:1-7. https://doi.org/10.1080/014805....
2.
Nazari M, Zarinkamar F, Shafaghat Z. Manganese modulates the physiological and biochemical responses of Mentha aquatica L. to ultraviolet radiation. J Trace Elem Med Biol. 2018;45:1-10. https://doi.org/10.1016/j.jtem... PMid:29173464.
3.
Baeeri M, Mohammadi-Nejad S, Rahimifard M, Navaei-Nigjeh M, Moeini-Nodeh S, Khorasani R, et al. Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. Mol Cell Biochem 2017;433:1-13. https://doi.org/10.1007/s11010....
4.
Okada F. Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression. Int J Cancer 2007;121:2364-72. https://doi.org/10.1002/ijc.23... PMid:17893867.
5.
Kato H, Nakazawa Y. Carbon tetrachloride and trichloroethylene toxicities to rat hepatocytes in primary monolayer culture: its relationship to the level of cytochrome P-450. Toxicol Lett. 1986;34:55-66. https://doi.org/10.1016/0378-4....
6.
Borges Sda S, Korn M, Lima JL. Chromium (III) determination with 1, 5-diphenylcarbazide based on the oxidative effect of chlorine radicals generated from CCl4 sonolysis in aqueous solution. Anal Sci. 2002;18:1361-6. https://doi.org/10.2116/analsc... PMid:12502090.
7.
Pawar R, Mohandass C, Sivaperumal E, Sabu E, Rajasabapathy R, Jagtap T. Epiphytic marine pigmented bacteria: A prospective source of natural antioxidants. Braz J Microbiol. 2015;46:29-39. https://doi.org/10.1590/S1517-... PMid:26221086 PMCid:PMC4512047.
8.
Mukherjee S, Thakur G, Kumar BD, Mitra A, Chakraborty C. Long-term effects of a carbohydrate-rich diet on fasting blood sugar, lipid profile, and serum insulin values in rural Bengalis. J Diabetes 2009;1:288-95. https://doi.org/10.1111/j.1753... PMid:20923529.
9.
Mohammadi J, Naik PR. Antidiabetic effects of Morus alba in experimentally induced diabetes in Wistar rat. Biomedicine 2008;28:112-116.
10.
Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, et al. Protective effects of total flavonoids of Bidensbipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Pharm Pharmacol 2008;60:1393-402. https://doi.org/10.1211/jpp.60... https://doi.org/10.1211/jpp/60... PMid:18812033.
11.
Delaviz H, Mohammadi J, Ghalamfarsa Gh, Mohammadi B, Farhadi N. A review study on Phytochemistry and pharmacology applications of Juglans regia plant. Pharmacognosy Reviews 2017;11:57-64.
12.
Mohammadi J, Taheri Motlagh F, Mohammadi N. The effect of hydroalcoholic extract of watercress on parameters of reproductive and sex hormones on the diabetic rats. J Pharm Sci Res. 2017;9:1334-38.
13.
Shahani S, Behzadfar F, Jahani D, Ghasemi M, Shaki F. Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity. Toxicol. Mech. Methods. 2017;27:107-114. https://doi.org/10.1080/153765... PMid:27825290.
14.
Porchezhian E, Ansari SH. Hepatoprotective effect of Abutilon indicumon experimental liver damage in rats. Phytomed 2005;12:62-64. https://doi.org/10.1016/j.phym... PMid:15693709.
15.
Keser G, Saygideger S. Effects of lead on the activities of antioxidant enzymes in watercress, Nasturtium officinale R. Br. Biol Trace Elem Res. 2010;137:235-43. https://doi.org/10.1007/s12011... PMid:19967468.
16.
Mohammadi J, Chatrroz B, Delaviz H. The effect of hydroalcoholic extract of capparis spinosa on quality of sperm and rate of testosterone following induction of diabetes in rats. Journal of Isfahan Medical School 2014;31:1-11.
17.
Banothu V, Neelagiri C, Adepally U, Lingam J, Bommareddy K. Phytochemical screening and evaluation of in vitro antioxidant and antimicrobial activities of the indigenous medicinal plant Albizia odoratissima. Pharm Biol. 2017;55:1155-1161. https://doi.org/10.1080/138802... PMid:28219296.
18.
Johnston DE, Kroening C. Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes. Pharmacol Toxicol. 1998;83:231-9. https://doi.org/10.1111/j.1600....
19.
El-Hadary AE, Ramadan Hassanien MF. Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Pharm Biol. 2016;54:1364-72. https://doi.org/10.3109/138802... PMid:26440388.
20.
Hyeong-seon l, li l, kim hk, bilehal d, li w, lee ds, et al. the protective effects of curcuma longa linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via up regulation of Nrf2. J Microbiol Biotechnol. 2010;20:1331–38. https://doi.org/10.4014/jmb.10....
21.
Shahrokhi N, Hadad M, Shabani M. Effects of aqueous extract of water cress on glucose and lipis plasma in streptozotocin induced diabetic rats. Pakistan Journal of Physiology 2009;5:6-10.
22.
Schmidt E, Schmidt FW, Mohr J, Otto P, Vido I, Wrogeman, K, et al. Liver morphology and enzyme release. Further studies in the isolated perfused rat liver. In: Keppler (Ed.) Pathogenesis and Mechanism of Liver Cell Necrosis. Medical and Technical Publishing Co. Ltd., Lancaster 1975;147.
23.
Ansari RA, Tripathi SC, Patnaik GK and Dhawan BN. Antihepatotoxic properties of picroliv, an active fraction from rhizomes of Picrorhiza kurroa. J Ethnopharmacol. 1991;34:61-68. https://doi.org/10.1016/0378-8....
24.
Ahmed MB, Hasona NAS, Selemain HAH. Protective effects of extract from dates (Phoenix dactyliferal.) and ascorbic acid on thioacetamide-induced hepatotoxicity in rats. Iranian Journal of Pharmaceutical Research 2008;7:193-201.
25.
Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S, Ichiba T. Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol Pharm Bull 2005;28:19-23. https://doi.org/10.1248/bpb.28... PMid:15635156.
26.
Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant–antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2007;560:110-116. https://doi.org/10.1016/j.ejph... PMid:17300777.
| eISSN: | 2516-3507 |
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