Aim: In this study we researched the effect of chronic hepatitis C virus (HCV) infection on serum lipid profile. Method: 28 patients (age average: 58.2±7.9 years) 17 of them women and 11 of them men and 33 healthy people (age average: 51.1±7.4 years) 22 of them women and 11 of them men taking chronic hepatitis C diagnosis through liver biopsy and in that any treatment wasn’t started yet were taken into the study. Liver biopsy samples were evaluated according to Knodell’s histology activity index. As once in the patient and control group, Albumin, platelet, total cholesterol, Apolipoprotein A1, Apolipoprotein A2, Apolipoprotein B, Apolipoprotein E, total lipid and other biochemical parameters were measured in the serum. Result: In patients with chronic hepatitis C, when compared with the control group, while alanine aminotransferase (104±11 and 21±11) IU/L, aspartat aminotransferase (74±5 and 19±7) IU/L and apolipoprotein A1 (137.68±38.46 and 119.27±19.84) mg/dl values were meaningfully high for each one (p<0.001), platelet (238±90 and 285±73) K/mm3, very-low density lipoprotein and total lipid values were found meaningfully low for each one (p<0.002). It wasn’t determined any relationship between liver stage, histological activity index (HAI) and lipid profile. Conclusion: HCV infection can lead to changes on serum lipid profile though its reason can’t be enlightened absolutely.