ORIGINAL ARTICLE
Factors related ART adherence and quality of life in PLHIV: Mediating role of positive self-care management and brain gym
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1
Faculty of Nursing, Airlangga University, Surabaya, INDONESIA
2
Faculty of Medicine, University of Malaya, Kuala Lumpur, MALAYSIA
3
Faculty of Nursing and Midwifery, Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA
4
STIKES Yarsi Mataram, Mataram, INDONESIA
Publication date: 2024-05-08
Electron J Gen Med 2024;21(3):em588
KEYWORDS
ABSTRACT
Objectives:
To investigate the factors affecting adherence to antiretroviral therapy (ART) and the quality of life in
people living with human immunodeficiency virus (HIV), with a focus on evaluating the mediating roles of positive
self-care management (PSCM) and brain gym.
Methods:
This is a descriptive study with a cross-sectional design. The data collected from June to August 2023.
There are 262 respondents selected through convenience sampling. We used various research instruments,
including questionnaires, which have undergone validity and reliability testing. The data were analyzed using the
SEM-PLS analysis method.
Results:
Our data analysis shows that condition factors, physical and social environmental factors, and individual
and family factors affect HIV individuals’ PSCM and brain gym combination, ART adherence, and quality of life.
Findings show that condition-specific factors indirectly affect antiretroviral drug adherence. This impact is
mediated by PSCM and brain gym.
Conclusions:
Specific condition variables, namely complexity of the disease, barriers, and stability of conditions
indirectly influence ART adherence, mediated through the combined influence of PSCM and brain gym. This
finding suggests that to enhance adherence and the quality of life among PLHIV, it is important to adopt an
approach that encompasses a range of internal and external individual factors.
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