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ORIGINAL ARTICLE
Glycemic control in children with type 1 diabetes: Insulin pump therapy versus multiple daily injections
1
Department of Internal Medicine, University Medical Center, Astana, KAZAKHSTAN
2
Department of Pediatrics, University Medical Center, Astana, KAZAKHSTAN
3
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
4
Department of Ophthalmology, Kazakh National Medical University named after S. D. Asfendiyarov, Almaty, KAZAKHSTAN
5
Department of Internal Medicine, Municipal Children’s Hospital №2, Astana, KAZAKHSTAN
6
Family Medicine Clinic, West Kazakhstan Marat Ospanov Medical University, Aktobe, KAZAKHSTAN
7
Regional Children’s Hospital, Shymkent, KAZAKHSTAN
8
Department of Medicine, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
Publication date: 2024-03-25
Electron J Gen Med 2024;21(2):em580
KEYWORDS
type 1 diabetes mellitusinsulin pump therapymultiple daily injectionsdegludeclong-actinginsulinshort-acting insulinsHbA1c
ABSTRACT
While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical
outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and
aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including
hemoglobin A1c (HbA1c), total daily insulin dosage, body mass index, glomerular filtration rate, in pediatric
patients with type 1 diabetes. In a linear mixed-effects regression analysis, a statistically significant interaction
between time and treatment type onHbA1c was found. It suggested significantly higher reduction of HbA1c values
between 12-month visit and baseline in the group receiving MDIs compared to insulin pump therapy. Patients
using MDIs observed higher reduction of HbA1c levels and lower total daily insulin dose relative to insulin pump
therapy group. Other changes of clinical indicators were the same for group of patients. Various studies report
controversial results on long term effects of these treatments on HbA1c values necessitating large population-based cohort studies in this field.
REFERENCES (37)
1.
Galiyeva D, Syssoyev D, Mussina K, et al. Epidemiology of diabetes mellitus in children in Kazakhstan: Data from unified national electronic health system 2014-2019. Endocr Abstr. 2022;22(1):275. https://doi.org/10.1530/endoab....
2.
Bradley SA, Banach M, Alvarado N, Smokovski I, Bhaskar SMM. Prevalence and impact of diabetes in hospitalized COVID-19 patients: A systematic review and meta-analysis. J Diabetes. 2022;14(2):144-57. https://doi.org/10.1111/1753-0... PMid:34939735 PMCid:PMC9060142.
3.
DiMeglio LA, Acerini CL, Codner E, et al. ISPAD clinical practice consensus guidelines 2018: Glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes. Pediatr Diabetes. 2018; 19(Suppl 27):105-14. https://doi.org/10.1111/pedi.1... PMid:30058221.
4.
Msanga D, Reis K, Kayange N, et al. Diabetic microvascular complications among children and adolescents in northwestern Tanzania: A cross-sectional study. Ann Glob Heal. 2020;86(1):43. https://doi.org/10.5334/aogh.2... PMid:32346524 PMCid:PMC7181947.
5.
Donaghue KC, Wadwa RP, Dimeglio LA, et al. Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes. 2014;15(S20):257-69. https://doi.org/10.1111/pedi.1... PMid:25182318.
6.
Danne T, Schwandt A, Biester T, et al. Long-term study of tubeless insulin pump therapy compared to multiple daily injections in youth with type 1 diabetes: Data from the German/Austrian DPV registry. Pediatr Diabetes. 2018;19(5):979-84. https://doi.org/10.1111/pedi.1... PMid:29446511.
7.
Neithercott T. The basics of insulin pumps. Minneapolis (MI): Medtronic; 2014. Available at: https://www.medtronicdiabetes.... (Accessed: 18 November 2023).
8.
Hamaty M. Insulin treatment for type 2 diabetes: When to start, which to use. Cleve Clin J Med. 2011;78(5):332-42. https://doi.org/10.3949/ccjm.7... PMid:21536829.
9.
Beck JK, Cogen FR. Outpatient management of pediatric type 1 diabetes. J Pediatr Pharmacol Ther. 2015;20(5):344-57. https://doi.org/10.5863/1551-6... PMid:26472948 PMCid:PMC4596120.
10.
The European Medicines Agency. Tresiba–Summary of product characteristics. Available at: https://www.ema.europa.eu/en/d... (Accessed: 18 November 2023).
11.
Cammarota S, Falconio LM, Bruzzese D, et al. Lower rate of cardiovascular complications in patients on bolus insulin analogues: A retrospective population-based cohort study. PLoS One. 2013;8(11):e79762. https://doi.org/10.1371/journa... PMid:24244557 PMCid:PMC3820645.
12.
Nathan DM. The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Overview. Diabetes Care. 2014;37(1):9-16. https://doi.org/10.2337/dc13-2... PMid:24356592 PMCid:PMC3867999.
13.
Chiang J, Kirkman M, Laffel L, Peters A, Type 1 Diabetes Sourcebook Authors. Type 1 diabetes through the life span. Diabetes Care. 2014;37(7):2034-54. https://doi.org/10.2337/dc14-1... PMid:24935775 PMCid:PMC5865481.
14.
Turan H, Tarcin G, Cakir A, et al. Assessment of two different insulin regimens in children with type 1 diabetes: A longitudinal study. Ann Med Res. 2022;29(2):103-7. https://doi.org/10.5455/annals....
15.
Pala L, Dicembrini I, Mannucci E. Continuous subcutaneous insulin infusion vs. modern multiple injection regimens in type 1 diabetes: An updated meta-analysis of randomized clinical trials. Acta Diabetol. 2019;56:973-80. https://doi.org/10.1007/s00592... PMid:30945047.
16.
Clements MA, Foster NC, Maahs DM, et al. Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry. Pediatr Diabetes. 2016;17(5):327-36. https://doi.org/10.1111/pedi.1... PMid:26153338.
17.
Jakisch BI, Wagner VM, Heidtmann B, et al. Comparison of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) in paediatric type 1 diabetes: A multicentre matched-pair cohort analysis over 3 years. Diabet Med. 2008;25(1):80-5. https://doi.org/10.1111/j.1464... PMid:18199134.
18.
Blair JC, McKay A, Ridyard C, et al. Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: Pragmatic randomised controlled trial and economic evaluation. BMJ. 2019;365: l1226. https://doi.org/10.1136/bmj.l1... PMid:30944112 PMCid:PMC6446076.
19.
Brorsson AL, Viklund G, Örtqvist E, Lindholm Olinder A. Does treatment with an insulin pump improve glycaemic control in children and adolescents with type 1 diabetes? A retrospective case-control study. Pediatr Diabetes. 2015;16(7):546-53. https://doi.org/10.1111/pedi.1... PMid:25327782.
20.
Al Shaikh A, Al Zahrani AM, Qari YH, et al. Quality of life in children with diabetes treated with insulin pump compared with multiple daily injections in Tertiary Care Center. Clin Med Insights Endocrinol Diabetes. 2020;13. https://doi.org/10.1177/117955... PMid:33088186 PMCid:PMC7545787.
21.
Dicembrini I, Pala L, Caliri M, et al. Combined continuous glucose monitoring and subcutaneous insulin infusion versus self-monitoring of blood glucose with optimized multiple injections in people with type 1 diabetes: A randomized crossover trial. Diabetes Obes Metab. 2020;22(8):1286-91. https://doi.org/10.1111/dom.14... PMid:32166907.
22.
Benkhadra K, Alahdab F, Tamhane SU, McCoy RG, Prokop LJ, Murad MH. Continuous subcutaneous insulin infusion versus multiple daily injections in individuals with type 1 diabetes: A systematic review and meta-analysis. Endocrine. 2017;55:77-84. https://doi.org/10.1007/s12020... PMid:27477293.
23.
Bergenstal RM, Tamborlane WV, Ahmann A, et al. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med. 2010;363:311-20. https://doi.org/10.1056/nejmoa... PMid:20587585.
24.
Hermanides J, Nørgaard K, Bruttomesso D, et al. Sensor-augmented pump therapy lowers HbA 1c in suboptimally controlled type1 diabetes; a randomized controlled trial. Diabet Med. 2011;28(10):1158-67. https://doi.org/10.1111/j.1464... PMid:21294770.
25.
Šoupal J, Petruželková L, Flekač M, et al. Comparison of different treatment modalities for type 1 diabetes, including sensor-augmented insulin regimens, in 52 weeks of follow-up: A COMISAIR study. Diabetes Technol Ther. 2016;18(9). https://doi.org/10.1089/dia.20... PMid:27482825 PMCid:PMC5035377.
26.
Jahn LG, Capurro JJ, Levy BL. Comparative dose accuracy of durable and patch insulin infusion pumps. J Diabetes Sci Technol. 2013;7(4):1011-20. https://doi.org/10.1177/193229... PMid:23911184 PMCid:PMC3879767.
27.
Borot S, Franc S, Cristante J, et al. Accuracy of a new patch pump based on a microelectromechanical system (MEMS) compared to other commercially available insulin pumps: Results of the first in vitro and in vivo studies. J Diabetes Sci Technol. 2014;8(6):1133-41. https://doi.org/10.1177/193229... PMid:25079676 PMCid:PMC4455475.
28.
Szypowska A, Schwandt A, Svensson J, et al. Insulin pump therapy in children with type 1 diabetes: Analysis of data from the SWEET registry. Pediatr Diabetes. 2016;17(S23):38-45. https://doi.org/10.1111/pedi.1... PMid:27417128.
29.
Alderisio A, Bozzetto L, Franco L, Riccardi G, Rivellese AA, Annuzzi G. Long-term body weight trajectories and metabolic control in type 1 diabetes patients on insulin pump or multiple daily injections: A 10-year retrospective controlled study. Nutr Metab Cardiovasc Dis. 2019;29(10): P1110-7. https://doi.org/10.1016/j.nume... PMid:31371264.
30.
Raile K, Noelle V, Landgraf R, Schwarz HP. Weight in adolescents with type 1 diabetes mellitus during continuous subcutaneous insulin infusion (CSII) therapy. J Pediatr Endocrinol Metab. 2002;15(2):607-12. https://doi.org/10.1515/jpem.2... PMid:12014519.
31.
Willi SM, Planton J, Egede L, Schwarz S. Benefits of continuous subcutaneous insulin infusion in children with type 1 diabetes. J Pediatr. 2003;143(6):P796-801. https://doi.org/10.1067/s0022-... PMid:14657831.
32.
Dimeglio LA, Pottorff TM, Boyd SR, France L, Fineberg N, Eugster EA. A randomized, controlled study of insulin pump therapy in diabetic preschoolers. J Pediatr. 2004; 145(3):P380-4. https://doi.org/10.1016/j.jped... PMid:15343195.
33.
Weintrob N, Benzaquen H, Galatzer A, et al. Comparison of continuous subcutaneous insulin infusion and multiple daily injection regimens in children with type 1 diabetes: A randomized open crossover trial. Pediatrics. 2003; 112(3):559-64. https://doi.org/10.1542/peds.1... PMid:12949284.
34.
Bartley PC, Bogoev M, Larsen J, Philotheou A. Long-term efficacy and safety of insulin detemir compared to neutral protamine hagedorn insulin in patients with type 1 diabetes using a treat-to-target basal-bolus regimen with insulin aspart at meals: A 2-year, randomized, controlled trial. Diabet Med. 2008;25(4):442-9. https://doi.org/10.1111/j.1464... PMid:18387078 PMCid:PMC2327220.
35.
Murphy NP, Keane SM, Ong KK, et al. Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens. Diabetes Care. 2003; 26(3):799-804. https://doi.org/10.2337/diacar... PMid:12610040.
36.
Wang F, Carabino JM, Vergara CM. Insulin glargine: A systematic review of a long-acting insulin analogue. Clin Ther. 2003;25(6):P1541-77. https://doi.org/10.1016/s0149-... PMid:12860485.
37.
Huang CY, Ting WH, Lo FS, Tsai JD, Sun FJ, Chan CI, et al. Factors associated with diabetic nephropathy in children, adolescents, and adults with type 1 diabetes. J Formos Med Assoc. 2017;116(12):924-32. https://doi.org/10.1016/j.jfma... PMid:29070437.
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