ORIGINAL ARTICLE
Glycemic control in children with type 1 diabetes: Insulin pump therapy versus multiple daily injections
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1
Department of Internal Medicine, University Medical Center, Astana, KAZAKHSTAN
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Department of Pediatrics, University Medical Center, Astana, KAZAKHSTAN
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Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
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Department of Ophthalmology, Kazakh National Medical University named after S. D. Asfendiyarov, Almaty, KAZAKHSTAN
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Department of Internal Medicine, Municipal Children’s Hospital №2, Astana, KAZAKHSTAN
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Family Medicine Clinic, West Kazakhstan Marat Ospanov Medical University, Aktobe, KAZAKHSTAN
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Regional Children’s Hospital, Shymkent, KAZAKHSTAN
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Department of Medicine, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
Publication date: 2024-03-25
Electron J Gen Med 2024;21(2):em580
KEYWORDS
ABSTRACT
While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical
outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and
aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including
hemoglobin A1c (HbA1c), total daily insulin dosage, body mass index, glomerular filtration rate, in pediatric
patients with type 1 diabetes. In a linear mixed-effects regression analysis, a statistically significant interaction
between time and treatment type onHbA1c was found. It suggested significantly higher reduction of HbA1c values
between 12-month visit and baseline in the group receiving MDIs compared to insulin pump therapy. Patients
using MDIs observed higher reduction of HbA1c levels and lower total daily insulin dose relative to insulin pump
therapy group. Other changes of clinical indicators were the same for group of patients. Various studies report
controversial results on long term effects of these treatments on HbA1c values necessitating large population-based cohort studies in this field.
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