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ORIGINAL ARTICLE
Hearing impairment in relation to vitamin D status in type 2 diabetic patients: A cross-sectional study
1
Department of ENT, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT
2
Department of ENT, Audiovestibular medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT
3
Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT
4
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT
5
Department of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT
6
Department of Biochemistry, College of Medicine, Taif University, Taif, SAUDI ARABIA
Online publication date: 2023-07-09
Publication date: 2023-09-01
Electron J Gen Med 2023;20(5):em526
KEYWORDS
ABSTRACT
Objectives:
To evaluate the association of serum 25 hydroxy vitamin D (25OHD) and hearing impairment type 2 diabetes mellitus (T2DM) patients. In addition, we aimed to examine whether T2DM-associated hearing impairment is correlated with the severity of diabetes.
Methods:
The present case-control study recruited adult patients with T2DM and healthy controls. Using pure-tone stimuli, we used an audiometer to assess the hearing thresholds of air conduction in each ear separately.
Results:
84 patients and 32 volunteers were included. The serum 25OHD was lower in T2DM patients than in healthy control (12.24±1.3 versus 23.19±5.69, respectively; p<0.001). The prevalence of vitamin D deficiency was 100% in the T2DM group, compared to 25% in the control group (p=0.001). T2DM patients exhibited higher hearing thresholds at all tested frequencies compared to the control group (p<0.001). Diabetic patients with hearing impairment had a significantly lower serum 25OHD than the normal hearing group (11.7±1.2 versus 12.6±1.2 ng/d; p=0.02). The multivariate analysis demonstrated that serum 25OHD level was an independent predictor of hearing loss among diabetic patients (β=-0.605; p=0.041).
Conclusions:
The present study highlights the potential role of vitamin D deficiency in developing hearing impairment in the setting of T2DM. We found a negative correlation between serum 25OHD level and air conduction thresholds at low-mid and high frequencies amongst patients with T2DM.
To evaluate the association of serum 25 hydroxy vitamin D (25OHD) and hearing impairment type 2 diabetes mellitus (T2DM) patients. In addition, we aimed to examine whether T2DM-associated hearing impairment is correlated with the severity of diabetes.
Methods:
The present case-control study recruited adult patients with T2DM and healthy controls. Using pure-tone stimuli, we used an audiometer to assess the hearing thresholds of air conduction in each ear separately.
Results:
84 patients and 32 volunteers were included. The serum 25OHD was lower in T2DM patients than in healthy control (12.24±1.3 versus 23.19±5.69, respectively; p<0.001). The prevalence of vitamin D deficiency was 100% in the T2DM group, compared to 25% in the control group (p=0.001). T2DM patients exhibited higher hearing thresholds at all tested frequencies compared to the control group (p<0.001). Diabetic patients with hearing impairment had a significantly lower serum 25OHD than the normal hearing group (11.7±1.2 versus 12.6±1.2 ng/d; p=0.02). The multivariate analysis demonstrated that serum 25OHD level was an independent predictor of hearing loss among diabetic patients (β=-0.605; p=0.041).
Conclusions:
The present study highlights the potential role of vitamin D deficiency in developing hearing impairment in the setting of T2DM. We found a negative correlation between serum 25OHD level and air conduction thresholds at low-mid and high frequencies amongst patients with T2DM.
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