Monkeypox is a rare disease originating in Africa and has recently gained the spotlight globally because of the increasing cases reported in Western Europe and North America. However, since July 2022, the World Health Organization has declared this disease a public health emergency of international concern as the cases were rising globally. We report a case of the severe form of rashes of hand-foot-and-mouth-disease to distinguish it from current outbreaks of the monkeypox virus. Hopefully, this case report will aid primary care physicians in their ability to recognize and distinguish between a severe hand-foot-and-mouth-disease rash and an infection with the monkeypox virus. So, effective management and treatment may aid patients in enhancing their quality of life.