REVIEW ARTICLE
Polypharmacy in the elderly: A bibliometric and visualization analysis
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1
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, JORDAN
2
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JORDAN
3
Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UAE
4
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JORDAN
5
Department of Physiology and Pharmacology/Toxicology, College of Medicine and Health Sciences, Nablus, PALESTINE
Online publication date: 2023-11-15
Publication date: 2024-01-01
Electron J Gen Med 2024;21(1):em555
KEYWORDS
ABSTRACT
Background:
The incidence of polypharmacy is increasing owing to population aging and the associated presence of multiple comorbidities. This study aimed to provide an extensive overview of the history and development of the scientific literature on polypharmacy.
Methods:
Data were gathered from the comprehensive Scopus database and assessed using various bibliometric methods, including analyses of citations, growth patterns, and key contributors in the field.
Results:
A notable upward trend in the publication rate of polypharmacy research was observed throughout the study period (1976-2022). Journal of the American Geriatrics Society emerged as the predominant platform for disseminating polypharmacy-related findings. Hughes CM from Queen’s University Belfast, the United Kingdom (UK), emerged as the most prolific author in this field. Most articles were authored by researchers affiliated with
institutions in the United States (n=267), the UK (n=92), and Italy (n=72).
Conclusions:
This study provides compelling evidence of the escalating interest in polypharmacy and momentum in related research, highlighting the crucial publication-related aspects and indicators in this field. The findings underline the value of bibliometric analyses as a tool for healthcare professionals. The wide dissemination, influence, and visibility of polypharmacy research in reputable scientific journals emphasize the urgent clinical need for addressing polypharmacy concerns and encourage further exploration in this area.
REFERENCES (57)
2.
Junius-Walker UG, Theile G, Hummers-Pradier E. Prevalence and predictors of polypharmacy among older primary care patients in Germany. Fam Pract. 2007;24(1):14-9.
https://doi.org/10.1093/fampra... PMid:17164234.
3.
Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230.
https://doi.org/10.1186/s12877... PMid:29017448 PMCid:PMC5635569.
4.
Hughes CM, Cooper JA, Ryan C. Going beyond the numbers–a call to redefine polypharmacy. Br J Clin Pharmacol. 2014;77(6):915-6.
https://doi.org/10.1111/bcp.12... PMid:24853404 PMCid:PMC4093916.
6.
Lu W-H, Wen Y-W, Chen L-K, Hsiao F-Y. Effect of polypharmacy, potentially inappropriate medications and anticholinergic burden on clinical outcomes: A retrospective cohort study. CMAJ. 2015;187(4):E130-7.
https://doi.org/10.1503/cmaj.1... PMid:25646290 PMCid:PMC4347788.
7.
Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57-65.
https://doi.org/10.1517/147403... PMid:24073682 PMCid:PMC3864987.
8.
WHO. Facts about ageing. World Health Organization; 2014. Available at:
https://www.who.int/ (Accessed: 23 February 2023).
9.
Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in prescription drug use among adults in the United States from 1999-2012. JAMA. 2015;314(17):1818-31.
https://doi.org/10.1001/jama.2... PMid:26529160 PMCid:PMC4752169.
14.
American Pharmacists Association, National Association of Chain Drug Stores Foundation. Medication therapy management in pharmacy practice: Core elements of an MTM service model (version 2.0). J Am Pharm Assoc. 2008;48(3):341-53.
https://doi.org/10.1331/JAPhA.... PMid:18595820.
15.
Almodovar AS, Nahata MC. Associations between chronic disease, polypharmacy, and medication-related problems among medicare beneficiaries. J Manag Care Spec Pharm. 2019;25(5):573-7.
https://doi.org/10.18553/jmcp.... PMid:31039057 PMCid:PMC10398061.
16.
Curtin D, Gallagher PF, O’Mahony D. Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences. Ther Adv Drug Saf. 2019;10:2042098619829431.
https://doi.org/10.1177/204209... PMid:30800270 PMCid:PMC6378636.
17.
Guthrie B, Payne K, Alderson P, McMurdo MET, Mercer SW. Adapting clinical guidelines to take account of multimorbidity. BMJ. 2012;345:e6341.
https://doi.org/10.1136/bmj.e6... PMid:23036829.
18.
Thompson W, Farrell B. Deprescribing: What is it and what does the evidence tell us? Can J Hosp Pharm. 2013;66(3):201-2.
https://doi.org/10.4212/cjhp.v... PMid:23814291 PMCid:PMC3694945.
19.
Aspinall S, Sevick MA, Donohue J, Maher R, Hanlon JT. Medication errors in older adults: A review of recent publications. Am J Geriatr Pharmacother. 2007;5(1):75-84.
https://doi.org/10.1016/j.amjo... PMid:17608250.
20.
Isetts BJ, Schondelmeyer SW, Artz MB, et al. Clinical and economic outcomes of medication therapy management services: The Minnesota experience. J Am Pharm Assoc (2003). 2008;48(2):203-14.
https://doi.org/10.1331/JAPhA.... PMid:18359733.
21.
Nkansah NT, Brewer JM, Connors R, Shermock KM. Clinical outcomes of patients with diabetes mellitus receiving medication management by pharmacists in an urban private physician practice. Am J Health Syst Pharm. 2008;65(2):145-9.
https://doi.org/10.2146/ajhp07... PMid:18192260.
22.
Pritchard A. Statistical bibliography or bibliometrics. J Doc. 1969;25:348-9.
23.
Wang B, Pan S-Y, Ke R-Y, Wang K, Wei Y-M. An overview of climate change vulnerability: A bibliometric analysis based on Web of Science database. Nat Hazards. 2014;74(3):1649-66.
https://doi.org/10.1007/s11069....
24.
Nafade V, Nash M, Huddart S, et al. A bibliometric analysis of tuberculosis research, 2007-2016. PLoS One. 2018;13(6):e0199706.
https://doi.org/10.1371/journa... PMid:29940004 PMCid:PMC6016906.
25.
Dwyer LL, Han B, Woodwell DA, Rechtsteiner EA. Polypharmacy in nursing home residents in the United States: Results of the 2004 national nursing home survey. Am J Geriatr Pharmacother. 2010;8(1):63-72.
https://doi.org/10.1016/j.amjo... PMid:20226393.
26.
Kojima T, Akishita M, Nakamura T, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425-30.
https://doi.org/10.1111/j.1447... PMid:22212467.
27.
Riker GI, Setter SM. Polypharmacy in older adults at home: What it is and what to do about it–Implications for home healthcare and hospice. Home Healthc Nurse. 2012;30(8):474-85.
https://doi.org/10.1097/NHH.0b... PMid:22936046.
28.
Rohrer JE, Garrison G, Oberhelman SA, Meunier MR. Epidemiology of polypharmacy among family medicine patients at hospital discharge. J Prim Care Community Health. 2013;4(2):101-5.
https://doi.org/10.1177/215013... PMid:23799716.
29.
Salih SB, Yousuf M, Durihim H, Almodaimegh H, Tamim H. Prevalence and associated factors of polypharmacy among adult Saudi medical outpatients at a tertiary care center. J Family Community Med. 2013;20(3):162-7.
https://doi.org/10.4103/2230-8... PMid:24672273 PMCid:PMC3957169.
30.
Harzing A-W, Alakangas S. Google Scholar, Scopus and the Web of Science: A longitudinal and cross-disciplinary comparison. Scientometrics. 2016;106(2):787-804.
https://doi.org/10.1007/s11192....
31.
Martín-Martín A, Orduna-Malea E, Thelwall M, López-Cózar ED. Google Scholar, Web of Science, and Scopus: A systematic comparison of citations in 252 subject categories. J Informetr. 2018;12(4):1160-77.
https://doi.org/10.1016/j.joi.....
32.
Mongeon P, Paul-Hus A. The journal coverage of Web of Science and Scopus: A comparative analysis. Scientometrics. 2016;106(1):213-28.
https://doi.org/10.1007/s11192....
33.
Fulton MM, Riley Allen E. Polypharmacy in the elderly: A literature review. J Am Acad Nurse Pract. 2005;17(4):123-32.
https://doi.org/10.1111/j.1041... PMid:15819637.
34.
Mortazavi SS, Shati M, Keshtkar A, Malakouti SK, Bazargan M, Assari S. Defining polypharmacy in the elderly: A systematic review protocol. BMJ Open. 2016;6(3):e010989.
https://doi.org/10.1136/bmjope... PMid:27013600 PMCid:PMC4809106.
35.
Veehof L, meyboom-de Jong B, Haaijer-Ruskamp FM. Polypharmacy in the elderly–A literature review. Eur J Gen Pract. 2009;6(3):98-106.
https://doi.org/10.3109/138147....
36.
Sweileh WM. Research trends on human trafficking: A bibliometric analysis using Scopus database. Glob Health. 2018;14:106.
https://doi.org/10.1186/s12992... PMid:30409223 PMCid:PMC6225706.
37.
van Eck, NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523-38.
https://doi.org/10.1007/s11192... PMid:20585380 PMCid:PMC2883932.
38.
Hovstadius B, Hovstadius K, Åstrand B, Petersson G. Increasing polypharmacy-an individual-based study of the Swedish population 2005-2008. BMC Clin Pharmacol. 2010;10:16.
https://doi.org/10.1186/1472-6... PMid:21122160 PMCid:PMC3014875.
39.
Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, web of science, and Google scholar: Strengths and weaknesses. FASEB J. 2008;22(2):338-42.
https://doi.org/10.1096/fj.07-... PMid:17884971.
40.
López-Muñoz F, Castle D, Shen W, et al. The Australian contribution to the literature on atypical antipsychotic drugs: A bibliometric study. Australas Psychiatry. 2013;21(4):343-5.
https://doi.org/10.1177/103985... PMid:23804115.
42.
Prazeres F, Passos L. Bibliometric analysis of the top 100 most cited articles on multimorbidity using the Dimensions database. Family Med Prim Care Rev. 2021;23(1):49-58.
https://doi.org/10.5114/fmpcr.....
43.
Dagli RJ, Sharma A. Polypharmacy: A global risk factor for elderly people. J Int Oral Health. 2014;6(6):i-ii.
44.
Nguyen JK, Fouts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36-41.
https://doi.org/10.1016/j.amjo... PMid:16730619.
45.
Bushardt RL, Massey EB, Simpson TW, Ariail JC, Simpson KN. Polypharmacy: Misleading, but manageable. Clin Interv Aging. 2008;3(2):383-9.
https://doi.org/10.2147/CIA.S2... PMid:18686760 PMCid:PMC2546482.
46.
Bornmann L, Daniel HD. The state of h index research: Is the h index the ideal way to measure research performance? EMBO Rep. 2009;10(1):2-6.
https://doi.org/10.1038/embor.... PMid:19079129 PMCid:PMC2613214.
48.
Jian D, Xiaoli t. Perceptions of author order versus contribution among researchers with different professional ranks and the potential of harmonic counts for encouraging ethical co-authorship practices. Scientometrics. 2013;96(1):277-95.
https://doi.org/10.1007/s11192....
49.
Walker RL, Sykes L, Hemmelgarn BR, Quan H. Authors’ opinions on publication in relation to annual performance assessment. BMC Med Educ. 2010;10:21.
https://doi.org/10.1186/1472-6... PMid:20214826 PMCid:PMC2842280.
50.
Du J, Tang X, Wu Y. The effects of research level and article type on the differences between citation metrics and F 1000 recommendations. J Assoc Inf Sci Technol. 2016;67(12):3008-21.
https://doi.org/10.1002/asi.23....
51.
van Weijen Dr D. The language of (future) scientific communication. Res Trends. 2007;1(31):3.
52.
Sweileh WM, Al-Jabi SW, AbuTaha AS, Zyoud SH, Anayah FMA, Sawalha AF. Bibliometric analysis of worldwide scientific literature in mobile-health: 2006-2016. BMC Med Inform Decis Mak. 2017;17(1):72.
https://doi.org/10.1186/s12911... PMid:28558687 PMCid:PMC5450106.
54.
Tam WWS, Wong ELY, Wong FCY, Cheung AWL. Citation classics in the integrative and complementary medicine literature: 50 frequently cited articles. Eur J Integr Med. 2012;4(1):e77-83.
https://doi.org/10.1016/j.euji....
55.
López-Navarro I, Moreno AI, Quintanilla MA, Rey-Rocha J. Why do I publish research articles in English instead of my own language? Differences in Spanish researchers’ motivations across scientific domains. Scientometrics. 2015;103(3):939-76.
https://doi.org/10.1007/s11192....
56.
Xu W, Zou Z, Pei J, Huang L. Longitudinal trend of global artemisinin research in chemistry subject areas (1983-2017). Bioorg Med Chem. 2018;26(20):5379-87.
https://doi.org/10.1016/j.bmc.... PMid:30279043.
57.
Samanci Y, Samanci B, Sahin E. Bibliometric analysis of the top-cited articles on idiopathic intracranial hypertension. Neurol India. 2019;67(1):78-84.
https://doi.org/10.4103/0028-3... PMid:30860102.