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ORIGINAL ARTICLE
Relation between airway cellular and bacterial findings and severity of COPD exacerbations: A multicentric study
1
Department of Chest Diseases, Al-Azhar University, Cairo, EGYPT
2
Department of Chest Diseases, Ain Shams University, Cairo, EGYPT
3
Department of Clinical Pathology, Al-Azhar University, Cairo, EGYPT
4
Department of Chest Diseases, Zagazig University, Zagazig, EGYPT
Online publication date: 2024-02-12
Publication date: 2024-03-01
Electron J Gen Med 2024;21(2):em573
KEYWORDS
ABSTRACT
Aim:
To evaluate the relationships between sputum and bronchoalveolar lavage (BAL) cellular and bacterial findings and severity of exacerbation of chronic obstructive pulmonary disease (ECOPD).
Patients & methods:
A cross-section study was conducted on 307 patients with ECOPD. They underwent sputum and BAL inflammatory cell count and bacterial culture.
Results:
Patients with severe ECOPD have significantly higher neutrophils percentage (neut.%), lower lymphocytes percentage (lymph.%), lower eosinophils percentage (eosin.%) and higher neutrophil/lymphocyte ratio (NLR) as compared to patients with mild ECOPD. It was also shown that patients with severe ECOPD had significantly higher BAL neut.%, lower lymph.%, lower eosin.%, and higher NLR as compared to the other two subgroups. Also, patients with severe ECOPD have significantly higher frequency of cases with monomicrobial (71.30% vs. 36.10%) and polymicrobial (21.25% vs. 2.10%) growths in comparison to patients with mild ECOPD.
Conclusions:
Cellular and bacterial findings in sputum and BAL are related to severity of ECOPD.
To evaluate the relationships between sputum and bronchoalveolar lavage (BAL) cellular and bacterial findings and severity of exacerbation of chronic obstructive pulmonary disease (ECOPD).
Patients & methods:
A cross-section study was conducted on 307 patients with ECOPD. They underwent sputum and BAL inflammatory cell count and bacterial culture.
Results:
Patients with severe ECOPD have significantly higher neutrophils percentage (neut.%), lower lymphocytes percentage (lymph.%), lower eosinophils percentage (eosin.%) and higher neutrophil/lymphocyte ratio (NLR) as compared to patients with mild ECOPD. It was also shown that patients with severe ECOPD had significantly higher BAL neut.%, lower lymph.%, lower eosin.%, and higher NLR as compared to the other two subgroups. Also, patients with severe ECOPD have significantly higher frequency of cases with monomicrobial (71.30% vs. 36.10%) and polymicrobial (21.25% vs. 2.10%) growths in comparison to patients with mild ECOPD.
Conclusions:
Cellular and bacterial findings in sputum and BAL are related to severity of ECOPD.
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