Aim: Alzheimer’s disease is one of the leading cause of all deaths worldwide , it contributes to a reduction in overall function and independent living and there is evidence that exercise can have an impact on the size, strength, and aerobic capacity of skeletal muscle in older people. This study was designed to detect changes in exercise tolerance and quality of life in Alzheimer's after aerobic exercise training in the form of walking and upper limbs exercises with the cycle ergometer. Method: Thirty patients with mild Alzheimer, their age ranged between 65 to 72 years and were included into 2 equal groups; group (A) received aerobic walking exercise training and upper limbs exercises with the cycle ergometer at a frequency of 3 sessions per week for two months. The second group (B) received no exercise training. Measurements of six minute walking test, hand grip strength and questionnaire of the quality of life (QOL) were obtained for both groups before and after the exercise program. Result: There was a significant increase in six minute walking test, hand grip strength and questionnaire of QOL of group (A), while the results of group (B) were not significant. There was a significant difference between both groups. Conclusion: aerobic exercise training program in the form of walking exercise and upper limbs exercises with the cycle ergometer for patients with Alzheimer's to improve their exercise tolerance and quality of life.