Although there are advantages of using Hem-o-lok clips in laparoscopic surgery, sometimes they can be the cause of the complication itself. Migration of Hem-o-Lok clips into the collecting system is a rare but a troublesome complication. We present a case of ureteropelvic junction (UP-J) migration of a Hem-o-lok clip after laparoscopic pyelolithotomy. In this case, the clip acts as a nidus for subsequent stone formation leading to a misdiagnosis as an UP-J obstructing stone. Finally it was managed with a rigid ureterorenoscopic approach. We concluded that, unless necessary, the use of Hem-o-lock clips should be avoided around the collecting system. In used cases we should be sure to place the clip a bit far away from the violated collecting system area in a tension free fashion.