Background:
Diabetes Mellitus is a degenerative disease that causes many complications in which blood glucose levels and oxidative stress increase that can cause liver damage and characterized by the increase in liver enzymes namely SGOT and SGPT. Kersen (Muntingia calabura L.) is one kind of plants that has antioxidant activity because it contains flavonoids to prevent oxidative stress.

Methods:
This study was an experimental research study design with pre and posttest control design. Thirty Sprague-Dawley rats were divided into 5 groups: group 1 (negative control), group 2 (metformin), group 3 (steeping kersen leaves of 250 mg/ 200 gr BW), group 4 (steeping kersen leaves of 500 mg/200 gr BW), and group 5 (steeping kersen leaves of 750 mg/200 gr BW). All groups induced with streptozotocine dose of 65 mg/kg BW and nicotinamide of 230 mg/kg BW for 5 days until the rats were with diabetes mellitus (fasting blood sugar> 135 mg/dl) and then given treatment for 14 days. GOD-PAP enzymatic method used glucose test, whereas a UV-Vis spectrophotometer used SGOT and SGPT test. Data were analyzed using paired t test and One Way Anova.

Results:
The results of statistical tests with paired t test showed significant differences in the levels of SGOT and SGPT before and after treatment (p=0.0001). One way Anova test shows that there is significant decrease in each group (p=0.0001).

Conclusion:
Steeping kersen leaves most effectively reduce levels of SGOT and SGPT in the dose of 750 mg/200 gr BW.