The nonadherence to prescriptions among type 2 diabetes patients, and its determining factors

Aim:
The aim is to clarify the prevalence of nonadherence to antidiabetic therapies among type 2 diabetes mellitus (T2DM) patients and identify its causes.

Methods:
A three-part questionnaire (general background, Knowledge-Attitude-Practice section, and non-adherence reasons) was developed. In total 324 diabetic patients were surveyed via telephone. The evaluation of patient adherence included both direct questions on adherence and a summary of patient responses to non-adherence comments. The analysis was performed on StataCorp Stata 14.2, and included descriptive analysis, simple and multivariate logistic regression.

Findings:
Among the sociodemographic variables, age group, work level, and alcohol consumption may influence medication adherence. The comorbidity status of patients was also of relevance. Both variables had stronger relationships with adherence to anti-diabetic treatments compared to those with no comorbidities or no additional medicines. A strength of the study is that it addresses various medical diseases and attitudes about them, as well as a wide range of causes for non-adherence to non-diabetic medications.

REFERENCES (13)

Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S. Growing pains: Non-adherence with the immunosuppressive regimen in adolescent transplant recipients. Pediatr Transplant. 2005;9(3):381-90. https://doi.org/10.1111/j.1399... PMid:15910397.

CrossRef

Pubmed

Google Scholar

Noble LM. Doctor-patient communication and adherence to treatment. In: Myers LB, Midence K, editors. Adherence to treatment in medical conditions. Reading (UK): Harwood Academic Publishers; 1998. p. 51-82. https://doi.org/10.1201/978100... PMid:33748533 PMCid:PMC7968045.

Carr AJ, Donovan JL. Why doctors and patients disagree. Br J Rheumatol. 1998;37(1):1-4. https://doi.org/10.1093/rheuma... PMid:9487242.

CrossRef

Pubmed

Google Scholar

WHO. Adherence to long term therapies: Evidence for action. World Health Organization; 2003. Available at: https://apps.who.int/iris/hand... (Accessed: 23 April 2023).

Google Scholar

Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment. JAMA. 2002;288(22):2880-3. https://doi.org/10.1001/jama.2... PMid:12472330.

CrossRef

Pubmed

Google Scholar

Sackett DL, Snow JC. The magnitude of compliance and non compliance. In: Haynes RB, Taylor DW, Sackett DL, editors. Compliance in health care. Baltimore, MD (USA): Johns Hopkins University Press; 1979. p. 11-22.

Google Scholar

Alekhya P, Sriharsha M, Priya Darsini T, et al. Treatment and disease related factors affecting non-adherence among patients on long term therapy of antidepressants. J Depress Anxiety. 2015;4(2):175. https://doi.org/10.4172/2167-1....

CrossRef

Google Scholar

Zheng Y, Ley S, Hu F. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2017;14(2):88-98. https://doi.org/10.1038/nrendo... PMid:29219149.

CrossRef

Pubmed

Google Scholar

Harvard Health. Type 2 diabetes mellitus. Harvard health; 2022. Available at: https://www.health.harvard.edu... (Accessed: 23 April 2023).

Google Scholar

10.

Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836-41. https://doi.org/10.1001/archin... PMid:17000939.

CrossRef

Pubmed

Google Scholar

11.

Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-97. https://doi.org/10.1056/NEJMra... PMid:16079372.

CrossRef

Pubmed

Google Scholar

12.

Araya EM, Gebrezgabiher HA, Tekulu GH, et al. Medication non-adherence and associated factors among diabetic patients visiting general hospitals in the Eastern Zone of Tigrai, Northern Ethiopia. Patient Prefer Adherence. 2020;14:2071-83. https://doi.org/10.2147/PPA.S2... PMid:33154631 PMCid:PMC7605964.

13.

Demoz GT, Berha AB, Woldu MA, Yifter H, Shibeshi W, Engidawork E. Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. PLoS ONE. 2019;14(10): e0222985. https://doi.org/10.1371/journa... PMid:31574113 PMCid:PMC6772059.