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CASE REPORT
The pathological and immunohistochemical profile of tumor angiogenesis in perforated sigmoid carcinoma–Case report and short literature review
1
Surgery Clinic, “Sf. Ap. Andrei” Emergency Clinical Hospital, Galati, ROMANIA
2
Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, ROMANIA
3
University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA
4
“Carol Davila” University of Medicine and Pharmacy, Bucharest, ROMANIA
5
Department of General Surgery, Dr. Ion Cantacuzino Hospital, Bucharest, ROMANIA
Online publication date: 2024-07-16
Publication date: 2024-09-01
Electron J Gen Med 2024;21(5):em600
KEYWORDS
ABSTRACT
Background:
Little is known about the physiopathological factors or mechanisms that underlie tumor invasion of the serosa and lead to perforation in the peritoneal cavity. The aim of the work was to analyze the pathological and immunohistochemical factors of tumor neoangiogenesis which could influence tumor perforation in colorectal cancer.
Results and discussions:
451 cases of complicated colorectal carcinomas were statistically analyzed, of which 19 cases were perforated sigmoid tumors. The immunohistochemical detection of mutant p53 proteins was the first molecular parameter examined in the context of the search for markers predicting the natural evolution mode in colorectal carcinomas.
Conclusions:
Both loss of p53 and overexpression of bcl-2 proteins confer immortalization on cancer cells by inhibiting the processes leading to apoptosis. The paper proposes a review of the specialized literature, but also the presentation of a clinical case.
Little is known about the physiopathological factors or mechanisms that underlie tumor invasion of the serosa and lead to perforation in the peritoneal cavity. The aim of the work was to analyze the pathological and immunohistochemical factors of tumor neoangiogenesis which could influence tumor perforation in colorectal cancer.
Results and discussions:
451 cases of complicated colorectal carcinomas were statistically analyzed, of which 19 cases were perforated sigmoid tumors. The immunohistochemical detection of mutant p53 proteins was the first molecular parameter examined in the context of the search for markers predicting the natural evolution mode in colorectal carcinomas.
Conclusions:
Both loss of p53 and overexpression of bcl-2 proteins confer immortalization on cancer cells by inhibiting the processes leading to apoptosis. The paper proposes a review of the specialized literature, but also the presentation of a clinical case.
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