REVIEW ARTICLE
The phenomenon of musical hallucinations: An updated review
 
 
More details
Hide details
1
Department of Psychiatry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA
 
 
Online publication date: 2023-08-01
 
 
Publication date: 2023-11-01
 
 
Electron J Gen Med 2023;20(6):em533
 
KEYWORDS
ABSTRACT
Introduction:
Musical hallucinations (MHs) is a heterogeneous phenomenon. Multiple case reports and series have improved our understanding of this complex phenomenon. This systematic review aims to assess the available evidence regarding MHs.

Methods:
PubMed and ProQuest databases were searched for articles published between 2005 and 2022. The keywords used for the search were “music,” “musical,” “hallucinations,” and “hallucinosis.”

Results:
The search identified 421 articles; however, only 67 were selected. A total of 77 patients were selected from case reports and series. We identified 50 articles with single cases, four articles with two cases, four articles with three cases, and one article with six cases. Eight additional articles that provided information regarding the prevalence of MHs were included in the review.

Conclusions:
MHs are common among older individuals, women, and hearing-impaired individuals. The etiologies include psychiatric, neurological, hearing impairments, and substances. Content of MHs is typically familiar songs/music. No randomized controlled studies are available for determining the treatment for MHs.

REFERENCES (85)
1.
Bentall RP. The illusion of reality: A review and integration of psychological research on hallucinations. Psychol Bull. 1990;107(1):82-95. https://doi.org/10.1037/0033-2... PMid:2404293.
 
2.
Sanchez TG, Rocha SC, Knobel KA, Kii MA, Santos RM, Pereira CB. Musical hallucination associated with hearing loss. Arq Neuropsiquiatr. 2011;69(2B):395-400. https://doi.org/10.1590/S0004-... PMid:21625772.
 
3.
Keshavan M, David A, Steingard S, Lishman W. Musical hallucinations: A review and synthesis. Cognitive and Behavioral Neurology. 1992;5(3):211-23.
 
4.
Evers S, Ellger T. The clinical spectrum of musical hallucinations. J Neurol Sci. 2004;227(1):55-65. https://doi.org/10.1016/j.jns.... PMid:15546592.
 
5.
Cope TE, Baguley DM. Is musical hallucination an otological phenomenon? A review of the literature. Clin Otolaryngol. 2009;34(5):423-30. https://doi.org/10.1111/j.1749... PMid:19793274.
 
6.
Moseley P, Alderson-Day B, Kumar S, Fernyhough C. Musical hallucinations, musical imagery, and earworms: A new phenomenological survey. Conscious Cogn. 2018; 65:83-94. https://doi.org/10.1016/j.conc... PMid:30077016 PMCid:PMC6204882.
 
7.
Linszen MMJ, van Zanten GA, Teunisse RJ, Brouwer RM, Scheltens P, Sommer IE. Auditory hallucinations in adults with hearing impairment: A large prevalence study. Psychol Med. 2019;49(1):132-9. https://doi.org/10.1017/S00332... PMid:29554989.
 
8.
Teunisse RJ, Olde Rikkert MG. Prevalence of musical hallucinations in patients referred for audiometric testing. Am J Geriatr Psychiatry. 2012;20(12):1075-7. https://doi.org/10.1097/JGP.0b... PMid:22327620.
 
9.
Schakenraad SM, Teunisse RJ, Olde Rikkert MG. Musical hallucinations in psychiatric patients. Int J Geriatr Psychiatry. 2006;21(4):394-7. https://doi.org/10.1002/gps.14... PMid:16570326.
 
10.
Degueure A, Fontenot A, Khan MW, Husan A. Music to the Ears: An unusual case of frontal lobe stroke with complex auditory hallucinations. Cureus. 2022;14(11):e31127. https://doi.org/10.7759/cureus....
 
11.
Baweja R, Hasoglu T, Joshi A. Musical hallucinations associated with adverse childhood events. Prim Care Companion CNS Disord. 2022;24(3):21cr03058. https://doi.org/10.4088/PCC.21....
 
12.
Zein M, Sher Y. Musical memories-musical hallucinations in a lung transplant recipient: Case report and literature review. J Acad Consult Liaison Psychiatry. 2021;62(1):140-9. https://doi.org/10.1016/j.psym... PMid:32977990.
 
13.
Stoyanov A, McDougall A, Urriola N. Musical hallucinations: A rare and atypical presentation of anti-IgLON5 disease responsive to immunosuppressive therapy. BMJ Case Rep. 2021;14(2):e236963. https://doi.org/10.1136/bcr-20... PMid:33602757 PMCid:PMC7896582.
 
14.
Schmitgen A, Saal J, Sankaran N, et al. Musical hallucinations in chronic pain: The anterior cingulate cortex regulates internally generated percepts. Front Neurol. 2021;12:669172. https://doi.org/10.3389/fneur.... PMid:34017308 PMCid:PMC8129573.
 
15.
Nordberg J, Taiminen T, Virtanen L, Jaaskelainen SK, Scheinin NM. Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report. Brain Stimul. 2021;14(6):1467-9. https://doi.org/10.1016/j.brs.... PMid:34597855.
 
16.
Montalvo A, Azevedo E, de Mendonca A. Shift of musical hallucinations to visual hallucinations after correction of the hearing deficit in a patient with Lewy body dementia: A case report. J Med Case Rep. 2021;15(1):449. https://doi.org/10.1186/s13256... PMid:34496966 PMCid:PMC8428060.
 
17.
Ferreira TF, Dehanov S, Figueiredo I, Santos NB. Musical hallucinations in a mixed episode-interaction between musicality and mood. Psychiatry Res. 2021;295:113633. https://doi.org/10.1016/j.psyc... PMid:33316729.
 
18.
Elikowski W, Malek-Elikowska M, Fertala N, Zawodna-Marszalek M. Amiodarone-induced musical hallucinations. Pol Merkur Lekarski. 2021;49(293):361-3.
 
19.
Canas-Simiao H, Nascimento ST, Reis J, Freitas C. Complex auditory musical hallucinations with ambivalent feelings. BMJ Case Rep. 2021;14(11):e245397. https://doi.org/10.1136/bcr-20... PMid:34764093.
 
20.
Muraosa H, Suzuki A, Noto K, Otani K. Musical hallucinations induced by conventional doses of paroxetine. Am J Case Rep. 2020;21:e926735. https://doi.org/10.12659/AJCR.... PMid:33361737 PMCid:PMC7768591.
 
21.
Buchwald N, Kelly A, Heilman KM, Simpkins AN. Musical hallucinations with a right frontotemporal stroke. Neurocase. 2020;26(5):313-6. https://doi.org/10.1080/135547... PMid:32930641.
 
22.
Song CI, Jung YE. Musical hallucination caused by ceftazidime in a woman with a hearing impairment. Clin Psychopharmacol Neurosci. 2019;17(2):326-8. https://doi.org/10.9758/cpn.20... PMid:30905135 PMCid:PMC6478083.
 
23.
Blackman G, Lim MF, Mannan F, David A. Transient musical hallucinations in a young adult male associated with alcohol withdrawal. Case Rep Psychiatry. 2019;2019:6546451. https://doi.org/10.1155/2019/6... PMid:31781460 PMCid:PMC6875172.
 
24.
Oladiran O, Nwosu I, Obanor S, Ogbonna-Nwosu C, LB. Anaplastic pleomorphic xanthoastrocytoma presenting with musical hallucination. Case Rep Neurol Med. 2018;2018:6428492. https://doi.org/10.1155/2018/6... PMid:30534452 PMCid:PMC6252228.
 
25.
Kobayashi Y. A case of traumatic brain injury presenting with musical hallucinations. Case Rep Neurol. 2018;10(1):7-11. https://doi.org/10.1159/000481... PMid:29515418 PMCid:PMC5836244.
 
26.
Doluweera Y, Suraweera C. Those who hear music: Three cases on musical hallucinations. Case Rep Psychiatry. 2018;2018:9361382. https://doi.org/10.1155/2018/9... PMid:30050719 PMCid:PMC6040295.
 
27.
Lee GH, Stewart JT. A case of musical hallucinations related to mirtazapine. Clin Neuropharmacol. 2018;41(6):222-3. https://doi.org/10.1097/WNF.00... PMid:30204598.
 
28.
Cavaliere C, Longarzo M, Orsini M, Aiello M, Grossi D. Fronto-temporal circuits in musical hallucinations: A PET-MR case study. Front Hum Neurosci. 2018;12:385. https://doi.org/10.3389/fnhum.... PMid:30319380 PMCid:PMC6170624.
 
29.
Niranjan V, Rastogi P, Razdan RG. “Musical ear syndrome”–Musical hallucinations in a patient with severe hearing loss–A report. Asian J Psychiatr. 2017;29:101-2. https://doi.org/10.1016/j.ajp.... PMid:29061401.
 
30.
Kitamura H, Saito M, Someya T. Two cases of musical hallucination successfully treated with quetiapine. Psychiatry Clin Neurosci. 2017;71(11):789. https://doi.org/10.1111/pcn.12... PMid:28853197.
 
31.
Alvarez Perez P, Garcia-Antelo MJ, Rubio-Nazabal E. “Doctor, I hear music”: A brief review about musical hallucinations. Open Neurol J. 2017;11:11-4. https://doi.org/10.2174/187420... PMid:28567134 PMCid:PMC5420178.
 
32.
Peritogiannis V, Menti N, Mavreas V. Atypical antipsychotics for the treatment of musical hallucinations in an elderly patient without a psychiatric disorder. J Neurosci Rural Pract. 2016;7(4):606-8. https://doi.org/10.4103/0976-3... PMid:27695252 PMCid:PMC5006484.
 
33.
Martinelli JE, Cecato JF, Aprahamian I. Brazilian national anthem presenting as musical hallucination: A case report with 9-year follow-up. Dement Neuropsychol. 2016;10(3):247-50. https://doi.org/10.1590/S1980-... PMid:29213463 PMCid:PMC5642423.
 
34.
Gandhi R, Narang P, Lippmann S. Are musical and auditory hallucinations related? Psychosomatics. 2016;57(4):442-3. https://doi.org/10.1016/j.psym... PMid:27283253.
 
35.
Borelli P, Vedovello M, Braga M, Pederzoli M, Beretta S. Persistent interictal musical hallucination in a patient with mesial temporal sclerosis-related epilepsy: First case report and etiopathological hypothesis. Cogn Behav Neurol. 2016;29(4):217-21. https://doi.org/10.1097/WNN.00... PMid:27984260.
 
36.
Joe S, Park J, Lim J, Park C. Unilateral musical hallucination after a hybrid cochlear implantation. Gen Hosp Psychiatry. 2015;37(1):97 e1-3. https://doi.org/10.1016/j.genh... PMid:25445069.
 
37.
Focseneanu BE, Marian G. Musical hallucinations–a challenge for psychiatric therapeutical management. Case report. J Med Life. 2015;8(4):533-5.
 
38.
Brunner JP, Amedee RG. Musical hallucinations in a patient with presbycusis: A case report. Ochsner J. 2015;15(1):89-91.
 
39.
Blom JD, Coebergh JA, Lauw R, Sommer IE. Musical hallucinations treated with acetylcholinesterase inhibitors. Front Psychiatry. 2015;6:46. https://doi.org/10.3389/fpsyt.... PMid:25904872 PMCid:PMC4387860.
 
40.
Woo PY, Leung LN, Cheng ST, Chan KY. Monoaural musical hallucinations caused by a thalamocortical auditory radiation infarct: A case report. J Med Case Rep. 2014;8:400. https://doi.org/10.1186/1752-1... PMid:25468292 PMCid:PMC4289290.
 
41.
Mansoor D, Ganzini L. Musical hallucinations successfully treated with antipsychotic medications: Three case reports. Psychosomatics. 2014;55(2):191-3. https://doi.org/10.1016/j.psym... PMid:23756119.
 
42.
Kataoka H, Ueno S. Auditory musical hallucinations associated with extended-release pramipexole in an elderly patient with Parkinson’s disease. Medicine (Baltimore). 2014;93(27):e251. https://doi.org/10.1097/MD.000... PMid:25501095 PMCid:PMC4602817.
 
43.
Husain F, Levin J, Scott J, Fjeldstad C. Recurrent refrains in a patient with multiple sclerosis: Earworms or musical hallucinations? Mult Scler Relat Disord. 2014;3(2):276-8. https://doi.org/10.1016/j.msar... PMid:25878018.
 
44.
Colon-Rivera HA, Oldham MA. The mind with a radio of its own: A case report and review of the literature on the treatment of musical hallucinations. Gen Hosp Psychiatry. 2014;36(2):220-4. https://doi.org/10.1016/j.genh... PMid:24359763.
 
45.
Bergman J, Pashinian A, Weizman A, Poyurovsky M. The beneficial effect of escitalopram on obsessive-compulsive-related musical hallucinations in elderly patients with hearing impairment: A case series. Int Clin Psychopharmacol. 2014;29(5):263-5. https://doi.org/10.1097/YIC.00... PMid:24810250.
 
46.
Aizawa S, Terao T, Hatano K, Ishii N. Musical hallucinations responding to a further increase of carbamazepine. BMJ Case Rep. 2014;2014. https://doi.org/10.1136/bcr-20... PMid:25253486 PMCid:PMC4173266.
 
47.
Vitorovic D, Biller J. Musical hallucinations and forgotten tunes–case report and brief literature review. Front Neurol. 2013;4:109. https://doi.org/10.3389/fneur.... PMid:23964264 PMCid:PMC3737457.
 
48.
Serby MJ, Hagiwara M, O’Connor L, Lalwani AK. Musical hallucinations associated with pontine lacunar lesions. J Neuropsychiatry Clin Neurosci. 2013;25(2):153-6. https://doi.org/10.1176/appi.n... PMid:23686034.
 
49.
Guclu O, Senormanci O, Guclu DG, Konkan R. Musical hallucinations of an unidentified melody. Gen Hosp Psychiatry. 2013;35(5):e7-8. https://doi.org/10.1016/j.genh... PMid:23347456.
 
50.
Zilles D, Zerr I, Wedekind D. Successful treatment of musical hallucinations with the acetylcholinesterase inhibitor donepezil. J Clin Psychopharmacol. 2012;32(3): 422-4. https://doi.org/10.1097/JCP.0b... PMid:22561476.
 
51.
Simoes S, Mesquita J, Marcal N, Santos M. Musical hallucinations: Case report and review of the literature. J Neuropsychiatry Clin Neurosci. 2012;24(2):E8. https://doi.org/10.1176/appi.n... PMid:22772708.
 
52.
Calabro RS, Baglieri A, Ferlazzo E, Passari S, Marino S, Bramanti P. Neurofunctional assessment in a stroke patient with musical hallucinations. Neurocase. 2012;18(6):514-20. https://doi.org/10.1080/135547... PMid:22224482.
 
53.
Bhatt YM, de Carpentier JP. Musical hallucination following whiplash injury: Case report and literature review. J Laryngol Otol. 2012;126(6):615-8. https://doi.org/10.1017/S00222... PMid:22643207.
 
54.
Huntley JD, Sandall A, Philpot M. “In the midnight hour”: A case report of musical hallucinations with multiple etiological factors treated with lamotrigine. Int Psychogeriatr. 2011;23(2):322-4. https://doi.org/10.1017/S10416... PMid:20950508.
 
55.
Wong CL, Bhalerao S. Post-surgery musical hallucinations of a patriotic Canadian song. Can J Neurol Sci. 2010;37(6):901-3. https://doi.org/10.1017/S03171... PMid:21059563.
 
56.
Shoyama M, Ukai S, Kitabata Y, et al. Evaluation of regional cerebral blood flow in a patient with musical hallucinations. Neurocase. 2010;16(1):1-6. https://doi.org/10.1080/135547... PMid:20391182.
 
57.
Kanemura S, Tanimukai H, Tsuneto S. Can “steroid switching” improve steroid-induced musical hallucinations in a patient with terminal cancer? J Palliat Med. 2010; 13(12):1495-8. https://doi.org/10.1089/jpm.20... PMid:21155649.
 
58.
Isolan GR, Bianchin MM, Bragatti JA, Torres C, Schwartsmann G. Musical hallucinations following insular glioma resection. Neurosurg Focus. 2010;28(2):E9. https://doi.org/10.3171/2009.1... PMid:20121444.
 
59.
Gondim Fde A, Costa HA, Taunay TC, de Oliveira GR, Ferreira JM, Rola FH. Transient amantadine-induced musical hallucinations in a patient with Parkinson’s disease. Mov Disord. 2010;25(10):1505-6. https://doi.org/10.1002/mds.22... PMid:20629118.
 
60.
Auffarth IS, Kropp S. Musical hallucination in a patient after cochlear implantation. J Neuropsychiatry Clin Neurosci. 2009;21(2):230-1. https://doi.org/10.1176/jnp.20... PMid:19622701.
 
61.
Williams VG, Tremont G, Blum AS. Musical hallucinations after left temporal lobectomy. Cogn Behav Neurol. 2008;21(1):38-40. https://doi.org/10.1097/WNN.0b... PMid:18327022.
 
62.
Ukai S, Yamamoto M, Tanaka M, Shinosaki K, Takeda M. Donepezil in the treatment of musical hallucinations. Psychiatry Clin Neurosci. 2007;61(2):190-2. https://doi.org/10.1111/j.1440... PMid:17362438.
 
63.
Satoh M, Kokubo M, Kuzuhara S. A case of idiopathic musical hallucination with increasing repertoire. J Neurol Neurosurg Psychiatry. 2007;78(2):203-4. https://doi.org/10.1136/jnnp.2... PMid:17229754 PMCid:PMC2077644.
 
64.
Mahendran R. The psychopathology of musical hallucinations. Singapore Med J. 2007;48(2):e68-70.
 
65.
Gentile S, Ferrero M, Giudice RL, Rainero I, Pinessi L. Abdominal pain associated with musical hallucinations: A case report. Eur J Neurol. 2007;14(11):e7-8. https://doi.org/10.1111/j.1468... PMid:17956440.
 
66.
Warren JD, Schott GD. Musical hallucinations in a musician. J Neurol. 2006;253(8):1097-9. https://doi.org/10.1007/s00415... PMid:16607470.
 
67.
Janakiraman R, Wildgoose K, Seelam K. ECT associated musical hallucinations in an elderly patient: A case report. Ann Gen Psychiatry. 2006;5:10. https://doi.org/10.1186/1744-8... PMid:16889667 PMCid:PMC1557851.
 
68.
Linszen MMJ, van Zanten GA, Teunisse RJ, Brouwer RM, Scheltens P, Sommer IE. Auditory hallucinations in adults with hearing impairment: A large prevalence study. Psychol Med. 2019;49(1):132-9.. https://doi.org/10.1017/S00332... PMid:29554989.
 
69.
Rocha SC, Kii MA, Pereira CB, Borelli DT, Forlenza O, Sanchez TG. Multidisciplinary assessment of patients with musical hallucinations, tinnitus and hearing loss. Psychopathology. 2015;48(4):251-5. https://doi.org/10.1159/000435... PMid:26278558.
 
70.
Golden EC, Josephs KA. Minds on replay: musical hallucinations and their relationship to neurological disease. Brain. 2015;138(Pt 12):3793-802. https://doi.org/10.1093/brain/... PMid:26446167.
 
71.
Aziz VM, Asaad M. Musical hallucination in acquired and pre-lingual deafness. Int Psychogeriatr. 2011;23(6):1015-7. https://doi.org/10.1017/S10416... PMid:23968300.
 
72.
Warner N, Aziz V. Hymns and arias: musical hallucinations in older people in Wales. Int J Geriatr Psychiatry. 2005;20(7):658-60. https://doi.org/10.1002/gps.13... PMid:16021667.
 
73.
Stephane M, Hsu LK, Hoffman R. About the mechanisms of musical hallucinations. Med Hypotheses. 1999;53(1):89-90. https://doi.org/10.1054/mehy.1... PMid:10499835.
 
74.
Griffiths TD. Musical hallucinosis in acquired deafness. Phenomenology and brain substrate. Brain. 2000;123(Pt 10):2065-76. https://doi.org/10.1093/brain/... PMid:11004124.
 
75.
Werhahn KJ, Mortensen J, Kaelin-Lang A, Boroojerdi B, Cohen LG. Cortical excitability changes induced by deafferentation of the contralateral hemisphere. Brain. 2002;125(Pt 6):1402-13. https://doi.org/10.1093/brain/... PMid:12023328.
 
76.
Ziemann U, Hallett M, Cohen LG. Mechanisms of deafferentation-induced plasticity in human motor cortex. J Neurosci. 1998;18(17):7000-7. https://doi.org/10.1523/JNEURO... PMid:9712668 PMCid:PMC6792971.
 
77.
Vanneste S, Song JJ, De Ridder D. Tinnitus and musical hallucinosis: The same but more. Neuroimage. 2013;82: 373-83. https://doi.org/10.1016/j.neur... PMid:23732881.
 
78.
Liikkanen LA, Raaska K. Treatment of anxiety from musical obsessions with a cognitive behaviour therapy tool. BMJ Case Rep. 2013;2013. https://doi.org/10.1136/bcr-20... PMid:24214156 PMCid:PMC3830214.
 
79.
Cosentino G, Giglia G, Palermo A, Panetta ML, Lo Baido R, Brighina F, et al. A case of post-traumatic complex auditory hallucinosis treated with rTMS. Neurocase. 2010;16(3):267-72. https://doi.org/10.1080/135547... PMid:20104391.
 
80.
Strauss M, Gertz H. Treatment of musical hallucinosis with acetylcholinesterase inhibitors. J Neurol Neurosurg Psychiatry. 2009;80(11):1298-9. https://doi.org/10.1136/jnnp.2... PMid:19864669.
 
81.
Coebergh JA, Lauw RF, Bots R, Sommer IE, Blom JD. Musical hallucinations: Review of treatment effects. Front Psychol. 2015;6:814. https://doi.org/10.3389/fpsyg.... PMid:26136708 PMCid:PMC4468361.
 
82.
Futamura A, Katoh H, Kawamura M. [Successful treatment with anti-epileptic-drug of an 83-year-old man with musical hallucinosis]. Brain Nerve. 2014;66(5):599-603.
 
83.
Holroyd S, Sabeen S. Successful treatment of hallucinations associated with sensory impairment using gabapentin. J Neuropsychiatry Clin Neurosci. 2008; 20(3):364-6. https://doi.org/10.1176/jnp.20... PMid:18806241.
 
84.
Tuerlings JH, Wijnen H, Boerman R, Verwey B. [Music as an uninvited guest: The auditive variant of the Charles Bonnet syndrome]. Tijdschr Psychiatr. 2009;51(11):853-8.
 
85.
Abdel-Aziz K, Pomeroy I. Ear worms and auditory Charles Bonnet syndrome. J Neurol Neurosurg Psychiatry. 2014; 85(10):e4. https://doi.org/10.1136/jnnp-2....
 
eISSN:2516-3507
Journals System - logo
Scroll to top