This study is conducted with the aim of the relationship between mindfulness and positive psychological skills on the response rate to pain in cancer patients in Alborz province by descriptive-correlational method. The population of the study consisted of 150 cancer patients (and a sample of 116 patients) who referred to Sarhad Abad Fardis Hospital in 2016-2017. They were selected using Morgan table and by the convenience method. In order to measure the variables used in the study, three questionnaires of Mindfulness, Positive Psychology and Response rate to Pain were used. According to inferential statistics, there is a positive and significant relationship between mindfulness and positive psychological skills in cancer patients (r = 0.657), which is significant at the alpha level of 0.01. There is also a negative and significant relationship between mindfulness and response rate to pain in cancer patients (r = -0.525), which is significant at the alpha level of 0.01. The results of regression analysis indicate that among the components of mindfulness, only one dimension (non-response) with beta coefficient, -0.52% as predictive variables has the criterion of entering the final equation of regression to explain changes of response rate to pain in cancer patients (criterion variable), the non-response alone can explain 0.27% of the response rate to pain in cancer patients.